简介:介绍了一种利用计算机编程实现在线调节坦克炮控制系统中PI参数的方法.它通过用VC++编写的上位机程序和用汇编语言编写的下位机程序,利用VC++6.0中的类CSerialP0rt完成了计算机和DSP(数字信号处理器)之间的通信,实现了在计算机上调节坦克炮控制系统中PI参数的功能.
简介:摘要:研究证实PI3K/Akt信号通路在调控成骨细胞、破骨细胞的骨代谢中发挥着重要作用,对维持人体骨稳态具有一定的意义。本文拟探讨该信号通路在成骨细胞分化、破骨细胞凋亡中的作用,并探析以miRNA为代表的非编码RNA在PI3K/AKt信号通路中调控骨代谢的作用机制,以期为骨代谢相关疾病的防治提供理论依据。
简介:<正>Byusingφ-mappingmethod,wediscussthetopologicalstructureoftheself-dualitysolutioninJackiw-Pimodelintermsofgaugepotentialdecomposition.WesetuprelationshipbetweenChern-Simonsvortexsolutionandtopologicalnumber,whichisdeterminedbyHopfindexandBrouwerdegree.Wealsogivethequantizationoffluxinthisease.Then,westudytheangularmomentumofthevortex,whichcanbeexpressedintermsof,theflux.
简介:Activationofthephosphoinositide3kinase(PI3K)/Akt/mammaliantargetofrapamycin(mTOR)pathwayiscommoninbreastcancer.Thereispreclinicaldatatosupportinhibitionofthepathway,andphaseⅠtoⅢtrialsinvolvinginhibitorsofthepathwayhavebeenorarebeingconductedinsolidtumorsandbreastcancer.Everolimus,anmTORinhibitor,iscurrentlyapprovedforthetreatmentofhormonereceptor(HR)-positive,humanepidermalgrowthfactorreceptor2(HER2)-negativebreastcancer.Inthisreview,wesummarisetheefficacyandtoxicityfindingsfromtherandomisedclinicaltrials,withsimplifiedguidelinesonthemanagementofpotentialadverseeffects.Educationofhealthcareprofessionalsandpatientsiscriticalforsafetyandcompliance.WhilethereissomeclinicalevidenceofactivityofmTORinhibitioninHR-positiveandHER2-positivebreastcancers,thebenefitsmaybemorepronouncedinselectedsubsetsratherthanintheoverallpopulation.FurtherdevelopmentofpredictivebiomarkerswillbeusefulintheselectionofpatientswhowillbenefitfrominhibitionofthePI3K/Akt/mTOR(PAM)pathway.
简介:Cytogeneticanalysiswasperformedforthebayscallop(ArgopectenirradiansLamarck1819)andtheJapanesescallop(PatinopectenyessoensisJay1857)byprimedinsitulabeling(PRINS)andpropidiumiodide(PI)bandingtechniques.ThePRINSanalysisrevealedthatmajorrRNAgeneswereclusteredintwolocionthetelomericregionsoftheshortarmsontwoacrocentricchromosomepairsinA.irradiansandontwosubmetacentricpairsinP.yessoensis.ThehistoneH3genesitesdifferedinnumberandlocationbetweenthesetwospecies.TheC-band-likepatternsrevealedbyPIstainingvariedconsiderablybetweenthesetwospecies.A.irradiansdisplayedterminalbandsatlongarmsonallchromosomes,centromericbandsonsomepairsandinterstitialbandsonfivepairs.P.yessoensisexhibitedonlycentromericbandsonallchromosomes.TheseresultswouldcontributetothebetterunderstandingofkaryotypeevolutioninA.irradiansandP.yessoensis.