简介:In[1],ShenGuangyuconstructedseveralclassesofnewsimpleLiealgebrasofcharacteristic2,whicharecalledthevariationsofG2.Inthispaper,theauthorsinvestigatetheirderivationalgebras.ItisshownthatG2anditsvariationsallpossessuniquenondegenerateassociativeforms.TheauthorsalsofindsomenonsingularderivationsofViGfori=3,4,5,6,andtherebyconstructsomeleft-symmetricstructuresonViGfori=3,4,5,6.Someerrorsaboutthevariationsofsi(3,F)in[1]arecorrected.
简介:Glioblastoma(GBM)isoneofthedeadliesttumorsandhasamediansurvivalof3monthsifleftuntreated.Despiteadvancesinrationallytargetedpharmacologicalapproaches,theclinicalcareofGBMremainspalliativeinintent.Sincethemajorityofalteredsignalingcascadesinvolvedincancerestablishmentandprogressioneventuallyaffectcellcycleprogression,analternativeapproachforcancertherapyistodevelopinnovativecompoundsthatblocktheactivityofcrucialmoleculesneededbytumorcellstocompletecelldivision.Inthiscontext,wereviewpromisingongoingandfuturestrategiesforGBMtherapeuticsaimedtowardsG2/Minhibitionsuchasanti-microtubuleagentsandtargetedtherapyagainstG2/Mregulatorslikecyclin-dependentkinases,Aurorainhibitors,PLK1,BUB,1,andBUBR1,andsurvivin.Moreover,wealsoincludeinvestigationalagentsinthepreclinicalandearlyclinicalsettings.Althoughseveraldrugswereshowntobegliotoxic,mostofthemhavenotyetenteredtherapeutictrials.TheuseofeithersingleexposureoracombinationwithnovelcompoundsmayleadtotreatmentalternativesforGBMpatientsinthenearfuture.
简介:ItisknownthatthereexistsanisogenysortofChevalleygroupsG(∑,F)associatedtoanyindecomposablerootsystem∑andanyfieldF.InthispapertheauthordeterminesallnontfivialhomomorphismsfromG(∑,k)toG(∑,K)whentherootsystem∑isoftypeCnorG2,andthefieldskandKarefinitefieldsofcharacteristiep.
简介:摘要目的应用液质联用(LC-MS/MS)技术,建立农产品中黄曲霉毒素B1、B2、G1、G2的定量检测方法,对市场中的农产品进行分析。方法样品粉碎后经乙腈水(84+16)提取,不经免疫亲和柱净化,氮吹浓缩定容后过0.22μm滤膜。滤液经反向C18柱分离,以0.1%甲酸水-甲醇作流动相梯度洗脱分离4种黄曲霉毒素。质谱采用电喷雾离子化源(ESI),正离子模式扫描。结果4种毒素在各自的定量范围内均呈良好的线性关系,r>0.990,回收率>80%,且与经免疫亲和柱净化相比,具有较高的回收率。结论该方法具有简便、快速、经济、灵敏、准确等优点,适用于多种农产品中黄曲霉毒素的检测。
简介:Objective:Squamousesophagealcarcinomaishighlyprevalentindevelopingcountries,especiallyinChina.TuBeiMu(TBM),atraditionalfolkmedicine,hasbeenusedtotreatesophagealsquamouscellcarcinoma(ESCC)foralongterm.tubeimosideI(TBMS1)isthemaincomponentofTBM,exhibitinggreatanticancerpotential.Inthisstudy,weinvestigatedthemechanismofTBMS1cytotoxiceffectonEC109cells.Methods:Comparativenuclearproteomicapproachwasappliedinthecurrentstudyandweidentifiedseveralalteredproteinspots.Furtherbiochemicalstudieswerecarriedouttodetectthemitochondrialmembranepotential,cellcycleandcorrespondingproteins’expressionandlocation.Results:SubcellularproteomicstudyinthenucleusfromEC109cellsrevealedthatalteredproteinswereassociatedwithmitochondrialfunctionandcellproliferation.FurtherbiochemicalstudiesshowedthatTBMS1-inducedmoleculareventswererelatedtomitochondria-inducedintrinsicapoptosisandP21-cyclinB1/cdc2complex-relatedG2/Mcellcyclearrest.Conclusions:ConsideringtheconventionalapplicationofTBMinesophagealcancer,TBMS1thereforemayhaveagreatpotentialasachemotherapeuticdrugcandidateforESCC.
简介:群对群(G2G)计算是一种基于G2G网络的分布式计算。G2G计算得益于灵活的分群,相同属性或任务的群内计算。本文提出了一个有门户网站结构,基于G2G计算的搜索服务。G2G搜索服务是一个混合搜索系统,既有分布式的搜索服务,又采用了集中式的搜索服务。采用G2G搜索服务的好处之一是,用户既参与了系统的分布式搜索任务,又能向系统请求搜索服务。采用G2G搜索服务的好处之二是,用部分的集中式结构把分散的局域搜索系统关联起来,扩大了系统的搜索效能。
简介:Inthispaper,buildingtogrid(B2G)andvehicletogrid(V2G)havebeendefinedwithclearandpracticalunderstanding.Bothofthemarenewgenerationtechnologieswhicharetheessentialpartofsmartcitylivingandcrowdenergyclustering.Firstly,anin-detailedoverviewhasbeenprovidedwithanintroductiontoB2GandV2Gfollowedbyahistoricaloverviewandtheoreticalanalysisinrespecttosmartcityplanning.Next,areviewisconductedoncurrentandprevioussmartlivingresearch,whichdealswithB2GandV2G.EfficientB2GandV2Gimplementationsinpracticalcasesthenhavebeendiscussed.Lastly,bothofthesetechnicalprospectshavebeenanalyzedincrowdenergydiagram.
简介:由群所组成且涉及群与群关系的网络称为G2G网络,群是一些具有相同属性节点的聚合。G2G通信可以描述为:将内容从源端(群)传送到目的群。G2G网络使用了G2G/CDS协议来实现内容发布,即将参与分发内容的节点分群,用控制数据集(CDS)来管理节点,用G2G传输原理来实现G2G传输。G2G/CDS简单和有效地解决了“如何管理节点”和“如何传输”的G2G通信问题,并为解决“如何保障传输的QoS”问题打下基础。G2G络是一种能有效且容易实现多对多网络通信的网络模型,擅长解决需要精确控制的网络通信问题,尤其是内容发布。