简介：Thepedagogyoflanguageteachinghasmovedfromoneextreme-GrammarTranslationMethodtotheother-CommunicativeLanguageTeaching.TodayFormFocusedInstruction(FFI)hasemerged,intendingtobringlanguageformsinstructionbacktothecommunicativelanguageclassroom.Despiteoftheapprovalofthisnewapproach,thereisahotdisputeonitstwotypesofapplication:FocusonFormorFocusonFormS.ThisarticlebrieflyanalyzesFFIinrecentresearchstudieswithfocusonthechoicebetweenthetwotypesofapplication.ThetentativeconclusionisFFIdoesshowsomeexplicitandreliableeffectsonaccuracyanderroreliminationinlanguageteaching;however,theinvestigationintoitsapplicationisnotsimplyeitherFocusonFormorFocusonFormS,butfocusesontheoptimalcombinationofthetwointeaching.

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简介：现在的学习是为检测HIFU调查微分成像方法(高紧张集中了超声)导致的损害和为有木头的损害评估的变细的变化的评价光谱差别算法。在vitro的牛的肌肉和肝的实验结果被获得。为损害察觉的几个算法-绝对差别(广告)，加绝对差别(悲伤)并且加摆平的差别(SSD)-与几种窗户尺寸和阀值价值被分析。当时，三个变细参数与相比评估织物的度损坏。它被发现吝啬的变细的那个变化()是一个有效参数评估损害。

简介：Objective:Toevaluatethesafetyandefficacyofexternalhigh-intensityfocusedultrasound(HIFU)castrationforbreastcancerouspatientsaftermastectomyiftheyareatahighriskofrecurrence.Methods:Werecruited52consecutivepatientswithprimaryoperablebreastcancerwhoweretreatedwithmastectomywithexcisionofregionallymphnodes.PatientswerepositiveforERandPRimmuno-cytochemicalstaining,node-positive,un-menopause,over40yearsoldandweredividedintotwogroupsrandomly.Forcastration,26patientsreceivedoneortwotimesofHIFUtreatmentwithinfivedays,andtheotherpatientsreceivedradiotherapywithDT18Gy/9f/11days.Duringandafterthetreatment,localchangesandsystemicresponseofthepatientswereobserved.Results:After1monthtreatment,levelsofserumE1andE2weresignificantlydecreasedcomparedtobeforetreatmentinHIFUgroups(P<0.01andP<0.001).Thesamechangeswereoccurredinradiotherapy(RT)groups(P<0.05andP<0.01).ThelevelsofserumE1orE2inRTgroupswerehigherthaninHIFUgroups(P<0.05).Thesymptomdistributionof'climactericsyndrome'ofHIFUgroupsweresignificantlydifferentfromRTgroups(P<0.01).Thefollow-uptimewas4months.Theincidenceofamenorrheawas100%inallpatients.Noseriouscomplicationswereseen.Thetemperature,pulse,bloodpressure,andrespiratoryrateofthepatientswerealmostnormal.Conclusion:WehaveshownthattheuseofHIFUinthecastratingofpatientswithbreastcancerisfeasible,safeandeffective.ThistechnologymayprovidearapidnoninvasivealterativetoconventionalbilateraloophorectomyorRTcastration.

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简介：Low-intensityfocusedultrasoundstimulation(FUS),whichpossesseshighspatialresolutionandpenetrationdepth,hasbeendevelopingrapidlyfornoninvasivebrainneuromodulationinrecentyears.Inthisletter,alow-intensityFUSsystemwasdevelopedfornoninvasivebrainneuromodulationinvivo.Theradiusofultrasonicfocalspotwasquantitativelycalculatedintheorytoevaluatethespatialresolution.Thelocalfieldpotential(LFP)ofrathippocompuswererecordedbeforeandafterFUS.TheeffectofFUSonLFPpowerspectrumwasinvestigatedbycomputingtheLFPmeanabsolutepowerandrelativepowerwithWelchalgorithm.TheexperimentresultsshowthatnoninvasiveFUScanenhanceLFPmeanabsolutepowerandaltertheLFPrelativepoweratdifferentfrequencybands.TheresultsindicatethatFUScanmodulatebrainrhythmsandhassignificantpotentialinthemodulationofneuronalandpsychiatricdiseases.

简介：AIM:Toinvestigatethedamagingeffectofhigh-intensityfocusedultrasound(HIFU)oncancercellsandtheinhibitoryeffectontumorgrowth.METHODS:MurineH22hepaticcancercellsweretreatedwithHIFUatthesameintensityfordifferentlengthsoftimeandatdifferentintensitiesforthesamelengthoftimeinvitro,thedeadcancercellsweredeterminedbytrypanbluestaining.TwogroupsofcancercellstreatedwithHIFUatthelowestandhighestintensitywereinoculatedintomice.Tumormasseswereremovedandweighedafter2wk,tumorgrowthineachgroupwasconfirmedpathologically.RESULTS:ThedeathrateofcancercellstreatedwithHIFUat1000W/cm2for0.5,1,2,4,8,and12swas3.11±1.21%,13.37±2.56%,38.84±3.68%,47.22±5.76%,87.55±7.32%,and94.33±8.11%,respectively.ApositiverelationshipbetweenthedeathratesofcancerceilsandthelengthofHIFUtreatmenttimewasfound(r=0.96,P＜0.01).ThedeathrateofcancercellstreatedwithHIFUattheintensityof100,200,400,600,800,and1000W/cm2for8swas26.31±3.26%,31.00±3.87%,41.97±5.86%,72.23±8.12%,94.90±8.67%,and99.30±9.18%,respectively.ApositiverelationshipbetweenthedeathratesofcancercellsandtheintensitiesofHIFUtreatmentwasconfirmed(r=0.98,P＜0.01).ThecancercellstreatedwithHIFUat1000W/cm2for8swereinoculatedintomiceexvivo.Thetumorinhibitoryratewas90.35%comparedtothecontrol(P＜0.01).IntheexperimentalgroupinoculatedwiththecancercellstreatedwithHIFUat1000W/cm2for0.5s,thetumorinhibitoryratewas22.9%(P＜0.01).Bypathologicalexamination,tumorgrowthwasconfirmedin8outof14mice(57.14%,8/14)inoculatedwiththecancercellstreatedwithHIFUat1000W/cm2for8s,whichwassignificantlylowerthanthatinthecontrol(100%,15/15,P＜0.05).CONCLUSION:HIFUiseffectiveonkillingordamageofH22hepaticcancercellsinvitroandoninhibitingtumorgrowthinmiceexvivo.

简介：Theredistributionoftheenergyflowoftightlyfocusedellipticity-variantvectoropticalfieldsispresented.Wetheoreticallydesignandexperimentallygeneratethiskindofellipticity-variantvectoropticalfield,andfurtherexploretheredistributionoftheenergyflowinthefocalplanebydesigningdifferentphasemasksincludingfanlikephasemasksandvortexphasemasksonthem.Theflexiblycontrolledtransverseenergyflowringsofthetightlyfocusedellipticity-variantvectoropticalfieldswithandwithoutphasemaskscanbeusedtotransportmultipleabsorptiveparticlesalongcertainpaths,whichmaybewidelyappliedinopticaltrappingandmanipulation.

简介：Inthisstudy,wenumericallyinvestigatedthenonlinearfocusedwavegroupactiononatruncatedsurface-piercingstructure,anddevelopedatwo-dimensionalfullynonlinearnumericaltankusingthehigher-orderboundaryelementmethod.WedeterminedtheamplitudeofthewavecomponentsofthefocusedwavegroupbasedontheJONSWAPwavespectrum.Wediscusstheeffectsofthepresenceofasurface-piercingstructureonthecharacteristicsofthefocusedwavegroupandfindthatthelocationofthestructuredoesnotevidentlychangethefocallocationorfocaltimeofthefocusedwavegroup.Thelargestamplitudesoftherun-upandhorizontalforceonthestructureoccurwhenthefrontsurfaceofthestructureisatthefocallocation.Thecriticaldraughtandbreadthofthestructureoccurwhenthewaverun-upreachesitsmaximumalongthestructure.

简介：Inthispaper,wederivetheanalyticalexpressionforthemultipoleexpansioncoefficientsofscatteringandinteriorfieldsofagraphene-coateddielectricparticleundertheilluminationofanarbitraryopticalbeam.Byusingthisarbitrarybeamtheory,wesystematicallyinvestigatetheopticalforcesexertedonthegraphene-coatedparticlebyafocusedGaussianbeam.Viatuningthechemicalpotentialofthegraphene,theopticalforcespectracouldbemodulatedaccordinglyatresonantexcitation.Thehybridizedwhisperinggallerymodeoftheelectromagneticfieldinsidethegraphene-coatedpolystyreneparticleismoreintensivelylocalizedthanthepurepolystyreneparticle,whichleadstoaweakenedmorphology-dependentresonanceintheopticalforces.Theseinvestigationscouldopennewperspectivesfordynamicengineeringofopticalmanipulationsinopticaltweezersapplications.

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简介：用向量衍射理论和现象学的模型，这份报纸调查集中的油炸圈饼横梁(DB)与不同拓扑的费用激动的单个中心对称的nanosphere的第二泛音代(SHG)。当粒子旁边是激动的时，强壮的向后的SHG(BSHG)出现的结果表演与拓扑的费用集中了DB????????????????￡吗？

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简介：Byinvestigatingthecross-spectraldensityofpartiallycoherentmulti-rotatingellipticalGaussianbeams(REGBs)thatpropagatethroughafocusingopticalsystem,weobtaintheradiationforceonaRayleighparticle.Theradiationforcedistributionisstudiedunderdifferentbeamindexes,coherencewidths,andellipticalratiosofthepartiallycoherentmultiREGBs.Thetransverseandthelongitudinaltrappingrangescanincreaseatthefocalplanebyincreasingthebeamindexordecreasingthecoherencewidth.Therangeofthetrappedparticleradiiincreasesastheellipticalratioincreases.Furthermore,weanalyzethetrappingstability.

简介：Systemictoxicityandinsufficientdrugaccumulationatthetumours让earemainbarriersinchemotherapy.Thermosens让iveliposomes(TSL)combinedwithhighintensityfocusedultrasound(HIFU)hasemergedasapotentialsolutiontoovercomethesebarriersthroughtargeteddrugdeliveryandlocalisedrelease.Owingtothemultiplephysicalandbiochemicalprocessesinvolvedinthiscombinationtherapy,mathematicalmodellingbecomesanindispensabletoolfordetailedanalysisofthetransportprocessesandpredictionoftumourdruguptake.Tothisend,amultiphysicsmodelhasbeendevelopedtosimulatethetransportofchemotherapydrugsdeliveredthroughacombinedHIFU-TSLsystem.Allkeydeliveryprocessesareconsideredinthemodel;theseineludeinterstitialfluidflow,HIFUacoustics,bioheattransfer;drugreleaseandtransport,aswellastumourdruguptake.Thecapabilityofthemodelisdemonstratedthroughitsapplicationtoa2-Dprostatetumourmodelreconstructedfrommagneticresonanceimages.Ourresultsnotonlydemonstratethefeasibilityofthemodeltosimulatethiscombinationtherapy,butalsoconfirmtheadvantageofHIFU-TSLdrugdeliverysystemwithenhancementofdrugaccumulationintumourregionsandreductionofdrugavailabilityinnormaltissue.ThismultiphysicsmodellingframeworkcanserveasausefultooltoassistinthedesignofHIFU-TSLdrugdeliverysystemsandtreatmentregimenforimprovedanticancerefficacy.

简介：摘要：本文首先基于用同一个模板产生的动态网页其内容往往是属于同一个主题的且其URL是非常相似的这个规律，提出了一个在Linux系统上实现的Focused Crawler Knowledge Graph（聚焦爬虫知识图谱），再根据基于URL规则的聚焦爬虫(URL Rule Based Focused Crawl，简称UBFC)的算法，即从严格限定主题相关网页范围、排除关键字、域名范围限定出发产生的BNF表达式，并用这些正则表达式来指导聚焦爬虫的抓取的理论，对此爬虫进行改进，使其在领域类收获率、召回率上获得较大改进。

简介：Despitewidespreadawarenessanduseofscientificallyprovenlife-prolongingmedicalanddevice-basedtherapiesoverthelasttwodecades,heartfailureremainsaleadingcauseofmorbidity,mortality,andhealthcareexpenditureintheUnitedStates.Mechanicalcirculatorysupportwithacontinuous-flowleftventricularassistdevice(CF-LVAD),eitherasabridgetohearttransplantationorasdestinationtherapy,isanincreasinglyusedtreatmentmodalityforpatientswithadvancedheartfailuresyndromesthatworsendespitetheirreceivingstandardtherapies.CF-LVADsupportcreatesuniquehemodynamicalterationsthatmustbeunderstoodtoprovideappropriatecareforthesepatientsbeforeandafterimplantation.EchocardiographyisessentialintheevaluationofpatientswhoarebeingconsideredfororaremechanicallysupportedbyCF-LVADs.Hereweprovideafocusedclinicalreviewontheuseofechocardiographyintwomainaspectsoftheevaluationofthesepatients:(a)optimalpatientselectionforCF-LVADsupportand(b)followupassessmentofoptimalpumpfunction.