简介：Thecasepresentedhereoffersusanopportunitytodiscussanincreasinglycommonlyconfrontedclinicalchallenge.Twoissuesareraised:howbesttomanagethepatient’svalvularheartdisease,includingboththeindicationsforsurgicalinterventionandtheprostheticoptions,andhowbesttomanagehisaorticdilatation.Letustakethemoneatatime.Thepatienthassevereaorticregurgitationbutanormalejectionfraction.Althoughwedonothavehisventriculardimensions,hehasaclassIindicationforinterventiongivenhissymptoms.
简介：Atheoreticalmodelthattakesintoaccountthefree-volumeaidedcooperativeshearingofsheartransformationzones(STZs)isdevelopedtoquantitativelyunderstandtheductile-to-brittletransition(DBT)ofmetallicglasses.TheSTZdilatationalstrainisdefinedastheratioofSTZ-activatedfreevolumetoSTZvolumeitself.ThemodeldemonstratesthattheSTZdilatationalstrainwillincreasedrasticallyandexceedthecharacteristicshearstrainofSTZastemperaturedecreasesbelowacriticalvalue.ThiscriticaltemperatureisingoodagreementwiththeexperimentallymeasuredDBTtemperature.OurresultssuggestthattheDBTofmetallicglassesisunderpinnedbythetransitionofatomic-clustermotionsfromSTZ-typerearrangementstodilatationalprocesses(termedtensiontransformationzones(TTZs)).
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