简介:摘要:目的分析慢性肝炎患者生命质量测定量表QLICD-CH研制中的条目筛选。方法选取30例慢性肝炎患者、25名医生与护士作为研究对象,使用定量调查分析结合定性访谈方式,筛选与评价最初的条目,分析结果。结果经过筛选与评价后,选定19个条目作为慢性肝炎患者生命质量评价表。结论生命质量测定量表QLICD-CH中筛选出19个条目作为慢性肝炎患者的生活质量评价指标。
简介:摘要:隧道施工是城市网络交通通行保障中的重要的一部分,而盾构机作为一种安全且有时效性的隧道掘进机械,在隧道推进种中得到了大范围的应用。由于上海市城市道路中心受各方面外部条件的制约,在市区的作业环境下基本采用上下层隧道设计,因此盾构机在南、北两个工作井先后下井吊装时存在高差,本文旨在探讨隧道项目中盾构设备下井吊装施工的技术要点,为相关工程提供参考。
简介:AbstractLeucine-rich repeats containing 4 (LRRC4, also named netrin-G ligand 2 [NGL-2]) is a member of the NetrinGs ligands (NGLs) family. As a gene with relatively high and specific expression in brain, it is a member of the leucine-rich repeat superfamily and has been proven to be a suppressor gene for gliomas, thus being involved in gliomagenesis. LRRC4 is the core of microRNA-dependent multi-phase regulatory loops that inhibit the proliferation and invasion of glioblastoma (GB) cells, including LRRC4/NGL2-activator protein 2 (AP2)-microRNA (miR) 182-LRRC4 and LRRC4-miR185-DNA methyltransferase 1 (DNMT1)-LRRC4/specific protein 1 (SP1)-DNMT1-LRRC4. In this review, we demonstrated LRRC4 as a new member of the partitioning-defective protein (PAR) polarity complex that promotes axon differentiation, mediates the formation and plasticity of synapses, and assists information input to the hippocampus and storage of memory. As an important synapse regulator, aberrant expression of LRRC4 has been detected in autism, spinal injury and GBs. LRRC4 is a candidate susceptibility gene for autism and a neuro-protective factor in spinal nerve damage. In GBs, LRRC4 is a novel inhibitor of autophagy, and an inhibitor of protein-protein interactions involving in temozolomide resistance, tumor immune microenvironment, and formation of circular RNA.
简介:摘要:以通辽地区耐密玉米品种为试材,研究了4+4大豆玉米带状复合种植模式下,玉米品种间产量及其产量构成因子差异。结果表明,TK601具有高产潜力,该品种适宜通辽地区大豆玉米带状复合种植模式。