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简介：Intoday'sInternetcomputingworld,illegalactivitiesbycrackersposeaseriousthreattocomputersecurity.Itiswellknownthatcomputerviruses,Trojanhorsesandotherintrusiveprogramsmaycausesevereandoftencatastrophicconsequences.Thispaperproposesanovelsecurecomputerarchitecturebasedonsecurity-code.Everyinstruction/datawordisaddedwithasecurity-codedenotingitssecuritylevel.Externalprogramsanddataareautomaticallyaddedwithsecurity-codebyhardwarewhenenteringacomputersystem.Instructionwithlowersecurity-codecannotrunorprocessinstruction/datawithhighersecuritylevel.Security-codecannotbemodifiedbynormalinstruction.Withminorhardwareoverhead,thenewarchitecturecaneffectivelyprotectthemaincomputersystemfromdestructionortheftbyintrusiveprogramssuchascomputerviruses.FormostPCsystems,itincludesanincreaseofword-lengthby1bitonregisters,thememoryandtheharddisk.

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简介：这回为大家介绍一个老牌国外木马．因为不能上网和程序比较狠所以就不拿自己机器做靶子了只给大家简单的介绍介绍功能。解压缩后得到以下两个文件。如图1所示。

简介：Itisproposedthatsomepossiblemacroseismicepicenterscanbedeterminedquicklyfromtherelationshipthatthemicroseismicepicenterslocatedbyinstrumentsbearwithfaults.Basedontheseso-calledmacroseismicepicenters,wecanmakefastseismichazardestimationafterashockbyuseoftheempiricaldistributionmodelofseismicintensity.Incomparisonwiththemethodthatusesthemicroseismicepicentersdirectly,thisapproachcanincreasetheprecisionoffastseismichazardestimation.Statisticalanalysisof133mainearthquakesinChinawasmade.Theresultshowsthatthedeviationdistancebetweenthemicroseismicepicenterandmacroseismicepicenterfallswithintherangeof35kmfor88%earthquakesofthetotalandwithintherangeof35to75kmfortheremainingones.Then,wecantaketheareathathasthemicroseismicepicenterasitscenterandis35kminradiusastheareaforemphaticanalysis,andtaketheareawithin75kmaroundthemicroseismicepicenterastheareaforgeneralanalysis.Therelationbetweenthe66earthquakecasesontheN-SSeismicBeltinChinaandthespatialdistributioncharacteristicsoffaultsandtheresultsoffocalmechanismsolutionwereanalyzedindetail.Weknowfromtheanalysisthattheerrorofinstrumentalepicenterdeterminationisnottheonlyfactorthatgiveseffectstothedeviationofthemacroseismicepicenter.Inadditiontoit,thefaultsize,faultdistribution,faultactivity,faultintersectiontypes,earthquakemagnitude,etc.arealsomainaffectingfactors.Bysortingout,processingandanalyzingtheseaffectingfactors,theprincipleandproceduresforquicklydeterminingthepossiblepositionofthemacroseismicepicenterweresetup.Takingtheseasabasisandestablishinganationwidedatabaseoffaultsthatcontainsrelevantfactors,itispossibletoapplythismethodinpracticalfastestimationofseismichazard.

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简介：这张手稿用设计策略的织物集中于骨头修理/新生，并且加亮导致新奇nanocomposite系统的nanobiotechnology开发。大约650万破裂在美国每年发生，并且大约550,000个这些单个盒子要求了骨头接枝的申请。自然发生并且allogenous骨头最广泛地为骨头接枝被使用了基于的治疗；然而，象施主缺乏和感染的风险那样有重要问题。用合成、自然的biomaterials的选择被开发了，并且一些为要求骨头接枝的临床的应用程序是商业地可得到的。然而，设计很仔细模仿骨头织物在结构上，和罐头的理想的合成接枝仍然是大挑战在造骨细胞和祖先房间人口调制需要的功能。Nanobiomaterials，明确地，nanocompositeshydroxyapatite创作了(哈)或骨胶原极其正在答应接枝代用品。biocomposites能被制作模仿本国的骨头织物的材料作文，并且另外，当使用nano时--哈(减少的谷物尺寸)，一个人模仿本国的骨头的结构的安排。骨头生物学和结构的好理解对骨头mimicking接枝代用品的开发批评。哈并且能进一步调制regenerative/healing的优秀osteoconductive性质处理跟随破裂损害的骨胶原展览。与另外的聚合biomaterials结合将增强因此做新奇nano的机械性质--哈比得上人的骨头的基于的composites。我们用nanocomposites在最近的研究上报导为部分骨头缺点的新生作为粒子和nanofibers被制作了。在nanocomposites的研究，在理想的未来发展加亮一个枢轴的角色整形外科植入设备，然而进一步的重要前进是必要的完成临床的使用。

简介：Glassbasedbonecement(GBC)wassynthesizedbymixingCaO-SiO2-P2O5basedglasspowderwithammoniumphosphateliquidmedium.Bone-likehydroxyapatite(HAP,Ca10(PO4)6(OH)2)wasfoundtoformafterGBCwasimmersedinsimulatedbodyfluid(SBF).HAPcrystalgrewwithanincreasingtimealongcaxleandreachedabout200nminlengthafter30days,however,theendplanegranularityremained30～50nm.Thechemicalcomposition,crystalstructureandmorphologyofHAPformedfromGBCwereprovedtohavegreatresemblancewithlivingHAP.ItisbelievedthatGBCwasadesirablebiomedicalmaterialwithhighbioactivity.Furthermore,thehighcompressivestrengthguaranteedthepossibilityofGBCinclinicalapplication.

简介：Objective:Toinvestigateanewmethodtoconstructtissue-engineeringbonethatwillbeapplicableclinically.　　Methods:　Thecultured5thgenerationrabbitbonemarrowstromaosteoblasts(MSO)wasdissolvedin3%sodiumalginatesolution(thefinalconcentrationofsodiumalginateinthesolutionbeing1%,andMSO,5×106/L),andtheninoculatedintopreparedtrueboneceramic(TBC)andgelatinizedthebonebydribblingwithcalciumgluconate.Thestandardbonedefectmodelsweremadein48adultNewZealandrabbitsbothradius.Amongthe48rabbits,24wereinGroupsAandB,inwhichtheleftradiuswasimplantedwithgelatinizedMSO-TBC(GroupA)andrightradiusimplantedwithautograft-bone(GroupB);andtheother24wereincontrolgroupwhoseleftradiuswasimplantedwithnon-gelatinizedMSO-TBC(GroupC)andrightradiusimplantedwithgelatinizedTBC(GroupD).Outcomesoftheimplantedboneswereassessedbyradiology,pathologicalhistology,osteogeneticquantitativeanalysis,andbiomechanicsat2,4,8,12weekspostoperatively.Results:　InGroupsAandB,asatisfactorybonereparationandbonyunionwasnotedwithin12weeks.InGroupsCandD,bonereparationwasnotsatisfiedcomparedwithGroupAintermsofostogeneticquantityandbiomechanics.　Conclusions:　GelatinizedMSO-TBCisanidealartificialactivebonethatovercomesTBCshortcomingsoffragilenessandsmoothsurfacethatisnoteligibleforseedcellsadhesion.Itispromisingtoputintoclinicaluseextensively.

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简介：AbstractType 1 diabetes (T1D) results from dysfunction of pancreatic islets β cells. Recent studies supported that endoplasmic reticulum (ER) stress takes an important role in pancreatic β cell excessive loss, resulting in T1D. Here, we aimed to review the relationship between ER stress and T1D. Additionally, we also reviewed the potential mechanisms underlying ER stress mediated T1D. Studies have shown that severe ER stress is directly involved in the pancreatic β cells destruction and pathogenesis of T1D. ER stress plays a key part in pancreatic β cells and T1D, which will help in developing new effective therapeutics for T1D.

简介：Anovertphenotypeofaquaporin-1knockout(AQP1ko)miceisgrowthretardation,suggestingpossibledefectsinbonedevelopmentandmetabolism.Inthepresentstudy,weanalyzedthebonemineraldensity(BMD),bonecalciumandphosphoruscontents,andbonemetabolisminanAQP1komousemodel.TheBMDoffemursinAQP1komicewassignificantlylowerthanthatoflitter-matchedwildtypemiceasmeasuredbydualenergyX-rayabsorptiometry.Consistently,thecontentsofbonetotalcalciumandphosphoruswerealsosignificantlylowerinAQP1komice.ThereducedBMDcausedbyAQP1deficiencymainlyaffectmalemice.Bonemetabolicactivity,asindicatedby99mTc-MDPabsorptionmeasurements,wasremarkablyreducedinAQP1komice.TheseresultsprovidethefirstevidencethatAQP1playanimportantroleinbonestructureandmetabolism.

简介：ToobservepotentialeffectoftheengineeredbonemarrowstromalcelllineQXMSC1secretingIL-6(QXMSCIL-6)onacceleratingimmnunereconstitutioninsyngeneicbonemarrowtransplantationinmice,QXMSC1wastransfectedwiththeeukaryocyticexpressionvectorpcDNAIL-6,whichcontainedhIL-6cDNAbyliposome-mediatedgenetransfectingtechnique.G418-resistanceclonewasselectedbylimitingdilution.ThehighestsecretingclonewasselectedbyELISAassayandusedinanimalexperiments.Therecipientmice(BALB/c)werelethallyirradiatedandcotransplantedsyngeneicbonemarrow(10^7/mice)andtheQXMSCIIL-6(5×10^5/mice).LymphocyteproliferationinducedbyConAandLPS,helperTlymphocyteprecursor(HTLp),cytotoxicTlymphocyteprecursor(CTLp),plaque-formingcell(PFC),delayedtypehypersensitivity(DTH)wereexamined30,60daysinposttransplantationrespectively.TheresultsshowedthatlymphocytesproliferationtoConAandLPS,HTLp,CTLpincreased,DTHandPFCwereimprovedbycograftedstromalcellsQXMSCIIL-6on30,60daysafterBMT.TheseresultsdemonstratedthatthebonemarrowstromalcelllineQXMSC1IL-6transfectedwithIL-6(QXMSC11L-6)acceleratedimmnunereconstitutioninsyngeneicbonemarrowtransplantation.

简介：Thecomplexityofacancer,suchascellheterogeneity,andtheexistenceofhypoxia,stromalcellsandstemcellshaspresent,theuseofconventionaltherapies,suchaschemo/radiotherapyislimited,andonlytherapiesthataresofarpreventedsuccessfuldevelopmentandtreatmentofpatientssufferingfromthelaterstagesofcancers.Atfocusedonutilizingthepatient'simmuneresponsetocombatagainstthediseaseappeartobethemostreliableandpromising.Twodecadesago,cytokineswerediscoveredtobeabletoactivatetheimnunesystemsandmountananti-tumourresponse.Then,dendriticcellswerehailedasthemostsignificantregulatorsofimmunityandareemployedinavarietyofcancermanagementschemes.Thisreviewintroducescurrentdevelopmentinthefield,focusingoncombinationofthecomponentsoftherapidlygrowingfieldsofimmunotherapyandgenetransfer/therapy,providingusefulandsignificantdetailedinformationforreadersofcellularandmolecularimmunology.Cellular&MolecularImmunology.

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简介：Paget'sdiseaseofboneisafocaldisorderofboneremodellingcausedbyabnormallyincreasedosteoclast-mediatedboneresorption.qtleaffectedboneschangeinshaw,sizeanddirection,whiletherestoftheskeletonremainsnormal.TheclinicalconsequencesofthediseasewerefirstdescribedbySirJanlesPagetin1876(Figure1).

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简介：你听说过GGBONE吗？就是那动画片中的猪猪侠，但是，你知道我的GGBONE吗，那就是我的QQ宠物猪猪。