简介：房间粘附在房间生理学起一个重要作用。这个过程的更好的理解能便于许多临床的治疗。在这研究，老鼠骨头导出髓的间充质的干细胞(rBMSCs)在玻璃底层上是有教养的，并且形态学和粘附力量被描绘。房间形态学被定义为球形，粘合剂，并且传播。不同形态学的粘附力量展出了不同分发模式。球形的房间展出了低粘附力量；当他们的直径仍然保持相对不变时，粘合剂房间展出了很快增加的粘附力量。粘附力量在传播房间与房间直径增加了。这些调查结果建议粘附力量能被检验房间形态学快速估计。

简介：Amechanicsmodelisdevelopedforthecontactradiusofstampswithpyramidtipsintransferprinting.Thisisimportanttotherealizationofreversiblecontrolofadhesion,whichhasmanyimportantapplications,suchasclimbingrobots,medicaltapes,andtransferprintingofelectronics.Thecontactradiusisshowntoscalelinearlywiththeworkofadhesionbetweenthestampandthecontactingsurface,andinverselywiththeplane-strainmodulusofthestamp.Italsodependsontheconeangleandtipradiu...

简介：Thevibrationmethodrepresentsapracticalmethodforthemeasurementofadhesionforcesandadhesionforcedistributions.Thismethodcausessinusoidallyalternatingstressesandyieldsdetachmentandcontactforcesbetweenparticlesandsubstrateofthesameorderofmagnitude.Alternatingcontactforcesofthevibrationmethodcancauseanadhesionforceintensificationthroughflatteningofasperities.Themeasuringprincipleofthevibrationmethodandtheanalysisofexperimentalresultsaredescribedinthearticle.Normaladhesionforces(pull-offforces)aremeasuredusingthevibrationmethodandthecolloidalprobetechnique.Theresultsofbothmethodsshowgoodagreementforsmallparticlesizes.Theinfluenceofthedetachmentforcedirectionisshownbycomparingtangentialandnormaladhesionforcesmeasuredusingparticlereentrainmentinaturbulentairflowandthevibrationmethod,respectively.Thesurfaceroughnessofthesubstrateandtherelativehumidityareshowntosignificantlyinfluencethemeasuredadhesionforces.Forthecalculationoftheadhesionforces,anapproachbyRabinovichwascombinedwithapproximationsofplasticmicroasperityflattening.TheRabinovichapproachaccountsforroughnesseffectsonthevanderWaalsforcebyincorporatingthermsroughnessoftheinteractingsurfaces,rms-valuesoftheparticlesandsubstratesweremeasuredwithatomicforcemicroscopyatdifferentscanningareas.

简介：Receptor-ligandinteractionsinbloodflowarecrucialtoinitiatesuchbiologicalprocessesasinflammatorycascade,plateletthrombosis,aswellastumormetastasis.Tomediatecelladhesion,theinteractingreceptorsandligandsmustbeanchoredontotwoapposingsurfacesoftwocellsoracellandasubstratum,i.e.,two-dimensional(2D)binding,whichisdifferentfromthebindingofasolubleligandinfluidphasetoareceptor,i.e.,three-dimensional(3D)binding.Whilenumerousworkshavebeenfocusedon3Dkineticsofreceptor-ligandinteractionsintheimmunesystem,2Dkineticsanditsregulationshavebeenlessunderstood,sincenotheoreticalframeworkorexperimentalassayswereestablisheduntil1993.Notonlydoesthemolecularstructuredominate2Dbindingkinetics,buttheshearforceinbloodflowalsoregulatescelladhesionmediatedbyinteractingreceptorsandligands.Here,weprovideanoverviewofcurrentprogressin2Dbindingandregulations,mainlyfromourgroup.Relevantissuesoftheoreticalframeworks,experimentalmeasurements,kineticratesandbindingaffinities,andforceregulationsarediscussed.

简介：Indryattachmentsystemsofspidersandgeckos,vanderWaalsforcesmediateattractionbetweensubstrateandanimaltarsus.Inparticular,thescopulaofEvarchaarcuataspidersallowsforreversibleattachmentandeasydetachmenttoabroadrangeofsurfaces.Hence,reproducingthescopula’sroughnesscompatibilitywhilemaintaininganti-bunchingfeaturesanddirtparticlerepellencebehaviorisacentraltaskforabiomimetictransfertoanengineeredmodel.InthepresentworkwemodelthescopulaofE.arcuatafromamechano-elasticpointofviewanalyzingtheinfluenceofitshierarchicalstructureontheattachmentbehavior.Byconsideringbiologicaldataofthegeckoandspider,andthesimulationresults,theadhesivecapabilitiesofthetwoanimalsarecomparedandimportantconfirmationsandnewdirectivesinordertoreproducetheoverallstructurearefound.Moreover,apossiblesuggestionofhowthespiderdetachesinaneasyandfastmannerisproposedandsupportedbytheresults.

简介：客观5-Aminoisoquinolinone，一水溶性，多形核白细胞(腺苷5'-diphosphate核糖)的活动的有势力禁止者聚合酶，在禁止多形核白细胞(腺苷5'-diphosphate核糖)的活动与ischaemia-reperfusion损害和发炎联系的织物损害起一个重要作用聚合酶和象ICAM-1那样的房间粘附分子的表示，P-selectin等。但是不在肿瘤它怎么样是清楚的。现在的学习的目的是在对人的脐的静脉endothelial的冒号癌线HT-29房间的粘附上学习5-Aminoisoquinolinon的效果；并且在结肠癌HT-29房间的ICAM-1，P-selectin和多形核白细胞(腺苷5'-diphosphate核糖)的活动聚合酶的表示上的5-Aminoisoquinolinon的效果。到人的脐的静脉endothelial的HT-29房间的粘附被粘合剂实验检测的方法。Immunocytochemically，Streptavidin-Peroxidase方法被用来调查ICAM-1，P-selectin和多形核白细胞(腺苷5'-diphosphate核糖)的表示(多形核白细胞(腺苷5'-diphosphate核糖)的产品聚合酶激活)。到HUVEC的HT-29房间的粘附试金的结果显示出的结果在每个5-AIQ-treated组的OD570价值是重要的，这以一种剂量依赖者方式在控制组(5-AIQ-untreated)比那降低。ICAM-1，P-selectin和多形核白细胞(腺苷5'-diphosphate核糖)的表示是重要的在HT-29房间在5-Aminoisoquinolinone-untreated组比那组织的5-Aminoisoquinolinone-treated更低。结论数据建议5-Aminoisoquinolinone能禁止HT-29房间的粘附到人的脐的静脉endothelial。5-Aminoisoquinolinone能也禁止多形核白细胞(腺苷5'-diphosphate核糖)聚合酶激活和在HT-29房间的ICAM-1和P-selectin的表情。5-Aminoisoquinolinone可能贡献肿瘤房间转移的预防。进一步的学习被需要。

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简介：Foridentifyingthetire/roadfrictioncoefficientaccuratelyinreal-timetomeettheneedsofautomobileelectroniccontrolsystemandthenimprovingtheactivesafetyperformanceofautomobile,theroadrecognitionmethodbasedonfuzzycontrolalgorithmwasstudiedinthispaper.Adopta7-DOFvehicledynamicmodel,wheelslipratioλandlongitudinalforcesFxastheinputoffuzzycontrollerwithfuzzyruleswasproposed.Theoutputistheweightcoefficientofμ-λfunctionalexpressionwhichisrelatedtoc1,c2andc3proposedbyBurckhardtetc.Byasimulationexperimentofautomobilebrakeontheconditionofdrivingstraightorveeringonasingleroadanddockingpavement,tosomeextent,indicatesthatthismethodisabletoguaranteethereal-timeandaccuracyoftheroadidentification.

简介：quasistatic一致设计被做为不平表面的粘附描绘有效连贯的地区行为。在一致设计的上下文，为一个不平的接口的一致连贯的地区(HCZ)的拖拉对分离关系能在显微镜的粘附和decohesion进程期间由于不稳定性是高度摆动的。不稳定性被发现不仅个别地而且一起发生在粘合剂之中微粗糙的接触，导致广泛的精力驱散。基于HCZ关系的行为，为在不平表面的粘附描述导致不稳定性的精力驱散的一个框架被建议阐明明显的接口粘附上的粗糙的效果。二个非维的参数，与粗糙形态学有关的伪和与aw分发有关的n，被识别为控制精力驱散很关键。为浅粗糙和强壮的内在的粘合剂力量的一个接口，如果我们使它更不平，接口粘附能更强壮(减少伪)或降低它的aw密度(增加的n)。HCZ设计方法能潜在地被扩大并且采用了为与多尺度的浅粗糙设计表面从内在的粘附性质衔接明显的粘附。

简介：Thispaperaimsatdevelopingastochastic-elasticmodelofasoftelasticbodyadheringonawavysurfaceviaapatchofmolecularbonds.Theelasticdeformationofthesystemismodeledbyusingcontinuumcontactmechanics,whilethestochasticbehaviorofadhesivebondsismodeledbyusingBell'stypeofexponentialbondassociation/dissociationrates.Itisfoundthatforsufficientlysmalladhesionpatchsizeorstressconcentrationindex,theadhesionstrengthisinsensitivetothewavelengthbutdecreaseswiththeamplitudeofsurfaceundulation,andthatforlargeadhesionpatchsizeorstressconcentrationindex,thereexistoptimalvaluesofthesurfacewavelengthandamplitudeformaximumadhesionstrength.

简介：Usingtheexperimentalresultsgiveninliteraturesaboutthecontactangle,θandtheworkofadhesion,W,fornonreactiveliquidmetal/solidUO2systems,thevalidityandfeasibilityofthedifferentexistingmodelsforcalculatingWinthemetal/ox-idesystemsarediscussed.Itcanbeshownthatthemodelsassumingthatonlymetalatom-oxygenioninteractionsexistingattheinterfacesareunabletoexplaintheexperimentalresultsforW.Morereasonablemodelshouldtakeintoaccountbothmetalatom-oxygenionandmetalatom-oxidemetalcationinteractions,theproportionofthelatterisbalancedbythestoichiometryoftheoxide.Byapplyingthemodelrecentlysetupbytheauthorsforbinaryalloy/oxidesystems,onecanusetheexperimentalandcalculatedvaluesofθandWforvariousmetal/UO2systemstopredicttheinfluenceofmetallicadditionsonthecontactangleandtheworkofadhesionofagivenmetal/UO2system.

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简介：最近的数字模拟显示了在cellsubstrate粘附期间聚类的integrin能被在房间膜和底层之间的排斥的层的存在驾驶(Paszek等，PLoSComputBiol5:12，2009)。这里我们在场在integrins之间的吸引力被膜和排斥的层的远程的有弹性的变丑在调停的这现象的一个简单力学模型。我们由采用在一个有弹性的基础上休息的一个无穷地扩大的盘子的小变丑理论获得分析答案到这个问题。

简介：Leukocyterollingandadhesionarecomplexphysiologicalprocessesthathavereceivedagreatdealofattentionoverthepastdecade.Significantincreasesintheknowledgebaserelatedtohowleukocytesadhereinshearflowshaveoccurredasaresultofthedevelopmentofnovelexperimentalandcomputationaltechniques.Micro-andnano-fabricationtechniqueshaveenabledthedevelopmentofnovelflowdevicesforstudyingleukocyteadhesioninsimpleandcomplexgeometries.Improve-mentsincomputertechnologyhaveenabledsimulationsofcomplexflowprocessestobedeveloped.Asaresultofthesead-vancesinknowledgerelatedtoleukocyteadhesion,numerousnoveldeviceshavebeendevelopedthatmimictheleukocyterollingandadhesionprocess.Examplesofthesedevicesincludecellseparationandenrichmentdevicesandtargetedultrasoundcontrastagents.Futureadvancesrelatedtoleukocyterollingandadhesionprocessesholdgreatpromiseforadvancingourknowledgeofdiseaseprocessesaswellasdevelopmentofnoveltherapeuticdevices.

简介：Onthebasisoftheexperimentalworkofadhesion(W)data,theadhesionbetweentransitionmetalcar-bidesandpureliquidmetalswhichdonotreactwithcarbidesisstudied.Inviewofgreatscatteringoftheex-perimentalvaluesofW,acriticalanalysisoftheseresultsisperformed.TheselectedWvaluesfor9copper/carbidesystemsand6metal/TiCsystemsareusedtodiscussthevarioussuggestionsconcerningthemechanismofadhesionandtoevidencetheroleofthevalenceelectronsofthebothcarbideandmetalontheinteractionsbetweenmetalsandcarbides.Theinteractionsbetweenametalandacarbideareessentiallymetal-licinteractions,resultingfromtheoverlappingofthevalenceelectronsatthemetal/carbideinterface.

简介：Capillaryforcesaresignificantlydominantinadhesiveforcesmeasuredwithanatomicforcemicroscope(AFM)inambientair,whicharealwaysthoughttobedependentonwaterfilmthickness,relativehumidity,andthefreeenergyofwaterfilm.Westudythenatureofthepull-offforceonavarietyofsurfacesasafunctionoftipvelocity.Itisfoundthatthecapillaryforcesareofrelativelystrongdependenceontipvelocity.ThepresentexperimentisexpectedtoprovideabetterunderstandingoftheworkmechanismofAFMinambientair.

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简介：objective:Theeffectsofdifferentchitosanonpreventingtraumaticperitonealadhesioninratswasstudiedinthispaper.METHODS:96SDratswithinjuredvermiformprocesswererandomlydividedinto4groupsasfollows:groupAwithoutanytreatmentascontrol,groupBtreatedwithchitosangel,groupCtreatedwithpurechitosanfilmandgroupDtreatedwithchistonfilmcontaining50%gelatin.2and4weeksaftersurgery,12ratsineachgroupwererespectivelybellyopenedtoobservechitosandegradationandevaluateperitonealadhesion,andtheadhesivevermiformprocessestissueswerehistopathologicallyobserved.RESULTS:1.DegraaxationinthegroupDwasfasterthanthatinthegroupCbutslowerthanthatinthegroupB.2.2weeksaftersurgerytheadhesioninthegroupBwasmilderthanthatinthecontrolgroup(goupA)(P＜0.05),butthatinthegroupCandD(bothP＜0.05)weremoreseverethanthatinthecontrolgroup.3.4weeksaftersurgery,theadhesioninthegroupBwasmilderthanthatinthecontrolgroup(P＜0.05),butthatinthegroupCandD(bothP＜0.05)weremoreseverethanthatinthecontrolgroup,whereas,therewasnosignificantdifferencebetweenadhesioninthegroupCandgroupD(P＞0.05).4.Histopathologicalexaminaitonindicatedthat:2weeksaftersurgery,inflammatorycellinfiltrationandfibroplasticproliferationdominatedinlocallesionandtheresponsewasmostseyereontheserouscoat,furthermore,theresponseinthecontrolgroupwasmoreseverethanthatinthegroupB,butmilderthanthatinthegroupCandD;4weeksaftersurgery,fibroplasticproliferationdominatedinlocallesionineachgroup,moreover,theresponseinthecontrolgroupwasmoreseverethanthatinthegroupBbutmilderthanthatinthegroupCandD.What'smore,integratedfibrousmembraneformedaroundimplantedmaterialsinthegroupCandD,andthefibrousmembraneswerethinnerinthegroupCthanthatinthegroupD.CONCLUSION:1.Chitosangelhasperfecteffe

简介：Stretchable/flexibleelectronicshasattractedgreatinterestandattentionduetoitspotentiallybroadapplicationsinbio-compatiblesystems.Oneclassoftheseultra-thinelectronicsystemshasfoundpromisingandimportantutilitiesinbio-integratedmonitoringandtherapeuticdevices.Thesedevicescanconformtothesurfacesofsoftbio-tissuessuchastheepidermis,theepicardium,andthebraintoprovideportablehealthcarefunctionalities.Uponcontractionsofthesofttissues,theelectronicsundergoescompressionandbucklesintovariousmodes,dependingonthestiffnessofthetissueandthestrengthoftheinterfacialadhesion.Thesebucklingmodesresultindifferentkindsofinterfacialdelaminationandshapesofthedeformedelectronics,whichareveryimportanttotheproperfunctioningofthebioelectronicdevices.Inthispaper,detailedbucklingmechanicsofthesethin-filmelectronicsonelastomericsubstratesisstudied.Theanalyticalresults,validatedbyexperiments,provideaveryconvenienttoolforpredictingpeakstrainintheelectronicsandtheintactnessoftheinterfaceundervariousconditions.