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简介：撒开手，让孩子自己走。相信他们，一路会走好！

简介：单词lonely、alone、only三词中文意思差不多,可含义与用法却不相同。望同学们注意三者各自的用法。一、lonely意思是“孤独的、寂寞的”,只作形容词用。指人孤独、寂寞的心境或指某一地方荒无人烟,并含有浓厚的伤感色彩。在句子中既可作表语又可作定语。如:

简介：alone和lonely是一对同义词，但它们的意义和用法有所不同，现简述如下：一、alone既可用作形容词，又可用作副词，意为“独自的(地)、单独的(地)”，侧重于说明独自一人，没有同伴或助手，指的是客观情况。

简介：喧器的尘世，熙攘的人群，留给我们独处的空间和时间屈指可数，而我们中有几个人能品味到那种独处着审视自己灵魂深处的安详与宁静呢？

简介：高中统编教材第一册第十九课里有这样一句:Beforeliberationhewasacart-driver,whocouldbarelykeepbodyandsoultogether,letalonesupporthisfamily.关于句中“letalone”的语法功能,众说纷云,看法不一,有的说它是副词和其后边的部分一起做状语,有的说它是连词片语,连接状语从句,还有的干脆说是词组做状语,等等。这几种看法我均不同意。下面就自己的看法,谈一下它在句中的语法功能,以与读者进行讨论。

简介：AbstractSeptoplasty is widely used in the treatment of structural nasal obstructions, and it also has a good effect and a high degree of postoperative satisfaction. However, there a large number of structures demonstrate abnormalities related to structural nasal obstruction, including the external nose, maxilla, nasal cavity and paranasal sinus. Nasal septum deviation is only one signs of structural nasal obstruction and does not represent all possible structural abnormalities of the nasal cavity and its surrounding structure. Septoplasty is only performed to correct deviations of the nasal septum, which in many cases is obviously insufficient in restoring the symmetry of the nasal structure. Therefore, septoplasty alone is not suitable for the treatment of most structural nasal obstructions. Nasal ventilation expansion surgery, which typically covers more abnormal structural correction procedures than septoplasty, should be used when describing the treatment of structural nasal obstruction.

简介：ConsideringbothChina'senergysecurityandthenon-renewabilityandscarcityoffossilfuels,developingnewenergies,realizingthetransformationofthenation'senergystructure,andreducingtherelianceonforeignenergyresourceswillbethelong-heldgoalsofthenationalenergypolicy.Inrecentyears,theChinesegovernmenthasintroducedaseriesofpreferentialpoliciestopromotethedevelopmentofnewenergies.Thelatestpolicyonelectricitypriceadjustmentannouncedattheendoflastyear,forinstance,involvedthestandardriseofsubsidiesforrenewableenergy,whichisexpectedtofacilitatethedevelopmentofnewenergies.

简介：1IntroductionEarlyattemptstocreateasoundabsorberwhichwouldfunctionwithouttheinvolvementofanyfibrousorporousdampingmaterialgofarbacktoK.A.Veliszhanina,S.N.RschevkinandothersaswasoutlinedinRef.[1].30yearsago,D.Y.MAA[2]wasfirstinproposingapracticabledesignconceptandcalculationmodelforMicro-PerforatedAbsorber(MPA)prototypeswhichstillformsthebasisforvariousapplications.Duringthepast12yearstheFraunhoferIBP

简介：ＴＨＥＲＡＰＥＵＴＩＣＥＦＦＥＣＴＳＯＦｒｈＴＮＦＡＬＯＮＥＡＮＤＩＮＣＯＭＢＩＮＡＴＩＯＮＷＩＴＨ　ＫＥＮＧＳＨＥＮＧＭＹＣＩＮＩＮＥＸＰＥＲＩＭＥＮＴＡＬＨＵＭＡＮＯＶＡＲＩＡＮＣＡＮＣＥＲＺｈａｏＥｎｆｅｎｇ赵恩锋；ＺｈｏｕＭｅｉｑｉｎｇ周美清...

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简介：Thisisareportofanonrandomizedcomparisonoftreatmentresultsof139patientswithstageIB,HAandproximalIIBcarcinomaoftheuterinecervixtreatedbyradiationaloneand113treatedwithacombinationofradiationandsurgery.Thefive-yeartumorfreeacturialsurvivalforthepatientswithstageIBeitherwithirradiationalone(RT)orcombinedwithsurgery(RS)wasapproximately87%.ForstageⅡthetumorfreeactuarialfive-yearsurvival79%withpatientsofRS,and76%withRT.Inthe113patientstreatedwithRStherewere18(16%).Inthe139patientstreatedbyRTtherewere18(13%)recurrencesofpelvic,4localrecurrences,11combinedwithparametrial,andfreeparametrialrecurrences.Therewasnosignificantdifferenceinthesurvivalandrecurrencerateofthepatientstreatedwitheithermethod.Majorcomplicationswerecomparableinbothgroups(RTapproximately25%andRSapproximately10%),but2/3ofthosecomplicationsrecoveredwithoutsequelae.Themostfrequentminor

简介：AIM:Tocomparetheclinicaloutcomesofcombined25-gaugeparsplanavitrectomy（PPV）andphacoemulsification/posteriorchamberintraocularlens（PC-IOL）implantationwithvitrectomyalonesurgeryinpatientswithvariousvitreoretinaldiseases.METHODS:Atotalof306eyes（145withPPValoneand161withphaco-vitrectomy）wereenrolledinthisretrospectiveanalysis.Thesurgicalapproachwas25-gaugePPVcombinedwithphacoemulsificationandPC-IOLimplantationatthesametimeineyesinphaco-vitrectomygroupandonlyPPVineyesinvitrectomyalonesurgerygroup.Themainoutcomemeasureswerepostoperativeclinicaloutcomesincludedanteriorchamberinflammation,changesinintraocularpressure（IOP）andbestcorrectedvisualacuity（BCVA）.RESULTS:Themostcommonpostoperativecomplicationwasanteriorchamberreactionwhichhashigherincidenceinphaco-vitrectomygroup（P<0.001）.Themeanpostoperative1stdayIOPofvitrectomyalonegroupwassignificantlylowerthanthatofphaco-vitrectomygroup（16.3±5.8mmHgvs17.8±8.1mmHg,respectively,P=0.02）.Hypotony(IOP（8mmHg）wasnotdifferentbetweengroupsinthepostoperative1stday（P>0.05）.Themeanpreoperativevisualacuitywasnotdifferentbetweengroups（1.6±0.9logMARvs1.8±0.9logMAR,respectively,P>0.05）.However,themeanvisualacuitywasdecreasedinvitrectomyalonegroupatthefinalvisitcomparedtophaco-vitrectomygroup（1.2±0.8logMAR,0.9±0.7logMAR,respectivelyP<0.05）.CONCLUSION:Twenty-fivegaugePPVcombinedwithphacoemulsificationsurgeryisasafeandefficientprocedure,whichcanbepreferredinphacicpatientswithavarietyofvitreoretinaldiseasescomparedtovitrectomyalone.Despiteimprovedoutcomes,thisapproachisnotfreeoflimitationsasanteriorchambercomplicationsespeciallywithcombinedsurgery.

简介：AbstractBackground:The neoadjuvant chemotherapy is increasingly used in advanced gastric cancer, but the effects on safety and survival are still controversial. The objective of this meta-analysis was to compare the overall survival and short-term surgical outcomes between neoadjuvant chemotherapy followed by surgery (NACS) and surgery alone (SA) for locally advanced gastric cancer.Methods:Databases (PubMed, Embase, Web of Science, Cochrane Library, and Google Scholar) were explored for relative studies from January 2000 to January 2021. The quality of randomized controlled trials and cohort studies was evaluated using the modified Jadad scoring system and the Newcastle-Ottawa scale, respectively. The Review Manager software (version 5.3) was used to perform this meta-analysis. The overall survival was evaluated as the primary outcome, while perioperative indicators and post-operative complications were evaluated as the secondary outcomes.Results:Twenty studies, including 1420 NACS cases and 1942 SA cases, were enrolled. The results showed that there were no significant differences in overall survival (P = 0.240), harvested lymph nodes (P = 0.200), total complications (P = 0.080), and 30-day post-operative mortality (P = 0.490) between the NACS and SA groups. However, the NACS group was associated with a longer operation time (P < 0.0001), a higher R0 resection rate (P = 0.003), less reoperation (P = 0.030), and less anastomotic leakage (P = 0.007) compared with SA group.Conclusions:Compared with SA, NACS was considered safe and feasible for improved R0 resection rate as well as decreased reoperation and anastomotic leakage. While unbenefited overall survival indicated a less important effect of NACS on long-term oncological outcomes.

简介：Objective:ToinvestigatetheeffectsofE7080andN5-(1-iminoethyl)-L-ornithinedihydrochloride(L-NIO)oncolorectalcanceraloneandincombination.Methods:HT29colorectalcancercelllinefromSapInstitutewasused.Real-timecellanalysis(xCELLigencesystem)wasperformedtodeterminetheeffectsofE7080andL-NIOoncolorectalcellproliferation.WhileapoptosiswasdeterminedwithAnnexinVstaining,andtheeffectofagentsonangiogenesiswasdeterminedwithchorioallantoicmembrane(CAM)model.Results:WefoundthatE7080hasastrongantiproliferativeeffectwithanhalfmaximuminhibitionofconcentration(IC50)valueof5.60×10–8mol/L.AlsoithasbeenobservedthatE7080showedantiangiogenicandapoptoticeffectsonHT29colorectalcancercells.AntiangiogenicscoresofE7080were1.2,1.0and0.6for100,10and1nmol/LE7080concentrations,respectively.Furthermore,apoptosishasbeendetectedin71%ofHT29colorectalcancercellsafteradministrationof100nmol/LE7080whichmayindicatestrongapoptoticeffect.MeanwhileadministrationofL-NIOalonedidnotshowanyeffect,butthecombinationofE7080withL-NIOincreasedtheantiproliferative,antiangiogenicandapoptoticeffectsofE7080.Conclusions:ResultsofthisstudyindicatethatE7080maybeagoodchoiceintreatmentofcolorectaltumors.FurthermoretheincreasedeffectsofE7080whencombinedwithL-NIOraisethepossibilitytousealowerdoseofE7080andthereforeavoid/minimizethesideeffectsobservedwithE7080.

简介：著名美藉摄影师@COLINSUSS联同创意总监@SHADY_BAGEL来到南加州著名国家公园-[JoshuaTree]，以公路式拍摄手法展示@carharttwip2017春夏造型、结合公园内的独特生态、沙漠质感及天然景观.

简介：在这回顾的研究，我们与先进前列腺癌症在中国病人独自评估了并且比较最大的雄激素封锁(MAB)对阉割的功效和毒性。从1996～2004，有先进前列腺癌症的608个病人在学习被包括。病人们回顾地根据不同治疗学的政体被划分成二个组。608个病人，300个病人与MAB(加nonsteroidalantiandrogens的阉割)并且留下被对待308独自与阉割被对待。这些病人的2年、5年的全面幸存率分别地是73.7%和56%。Multivariate分析证明在有变形前列腺癌症的病人，MAB与没有前进的幸存(PFS)的改进被联系不仅(到10个月增加了)而且在死亡风险的20.6%减小与阉割相比独自一个。相反，MAB的功效不比为有nonmetastatic前列腺癌症的病人独自一个的阉割优异。在有MAB的病人之中，有趣地，那些使用的bicalutamide用flutamide比那些有更长的PFS；这是特别在有变形前列腺癌症的病人。几乎所有毒性，由于荷尔蒙，治疗对温和中等、可管理。得出结论在中国，荷尔蒙治疗，包括的MAB和阉割独自一个，是为先进前列腺癌症的标准治疗。为有nonmetastatic前列腺癌症的病人，阉割可能独自足够地实际、有效。在有变形前列腺癌症的病人，然而，MAB独自在阉割上有优异功效。MAB应该与变形前列腺癌症为病人被认为首要的标准治疗，是清楚的。

简介：在这份报纸，我们独自考察了雄激素剥夺治疗(ADT)的长期的幸存结果，安全，和quality-of-life对为局部地先进、变形的前列腺癌症(PCa)与放射治疗(RT)或化疗结合了。文学搜索用OvidSP被执行。满足了下列标准的使随机化的控制试用(RCT)被包括：包括局部地先进或变形的PCa，比较方法和疾病的报导量的数据控制的与任何治疗独自一个对联合的ADT或幸存结果。最后，八RCT满足了包括标准。在这些之中，三比较了ADT对ADT正RT(n=2344)并且一个人比较了ADT对ADT正docetaxel-estramustine(n=413)在局部地先进的PCa；二比较了ADT对ADT正docetaxel(n=1175)并且加estramustine的二比较ADT对ADT(n=114)在变形PCa。为局部地先进的PCa，到长期的ADT的RT的增加能与充分可接受的不利效果改进幸存和肿瘤控制的结果。特殊，分享的机会比率(或)外套，幸存(OS)是1.43(95%信心间隔1.20-1.71)什么时候独自加RT把ADT与ADT作比较(P<0.0001)。为变形神经质地敏感的PCa，加ADT的docetaxel的并发的使用有效、安全(分享或OS：1.29[1.01-1.65]：P=0.04)。总共，加docetaxel的长期的ADT正RT和长期的ADT应该分别地在局部地先进、变形的神经质地敏感的PCa被看作合适的处理选择。为纸的主要限制是仅仅八RCT是可得到的。

简介：AbstractPurpose:Combined anterior and posterior ring (APR) fixation is classically performed in Tile B2 and C1 injuries to achieve superior biomechanical stability. However, the posterior ring (PR) is the main weight bearing portion that is responsible for weight transmission from the upper parts of the body to the lower limbs through the sacrum and the linea terminalis. It is hypothesized that isolated PR fixation can achieve comparable radiological and clinical outcomes to APR fixation. Therefore, we conducted this study to compare the two fixation principles in managing Tile B2 and C1 injuries.Methods:Our study included 20 patients with Tile B2 injuries and 20 patients with Tile C1 injuries. This study was a randomized control single-blinded study via computerized random numbers with a 1:1 allocation by using random block method. The study was performed at a level one trauma center. A total of 40 patients with Tile B2 and C1 injuries underwent combined APR or isolated PR fixation (Group A and B, respectively). Matta & Tornetta radiological principles and Majeed pelvic scoring system were used for the assessment of primary outcomes and postoperative complications. Secondary outcomes included operative time, amount of blood loss, intraoperative assessment of reduction, need of another operation, length of hospital stay, ability to weight bear postoperatively and pain control metrics. We used student t-test to compare the difference in means between two groups, and Chi-square test to compare proportions between two qualitative parameters. We set the confidence interval to 95% and the margin of error accepted to 5%. So, p ≤ 0.05 was considered statistically significant.Results:The mean follow-up duration was 18 months. The operative time (mean difference 0.575 h) and the intraoperative blood loss (mean difference 97.5 mL) were lower in Group B. Also, despite the higher frequency of rami displacement before union in the same group, there were no significant differences in terms of radiological outcome (excellent outcome with OR = 2.357), clinical outcome (excellent outcome with OR = 2.852) and postoperative complications assessment (OR = 1.556) at last follow-up.Conclusion:The authors concluded that isolated PR fixation could favorably manage Tile B2 and C1 pelvic ring injuries with Nakatani zone II pubic rami fractures and intact inguinal ligament. Its final radiological and clinical outcomes and postoperative complications were comparable to combined APR fixation, but with less morbidity (shorter operation time, lower amount of blood, and no records of postoperative wound infection).

简介：AbstractBackground:Till date, the optimal treatment strategy for delivering adjuvant androgen deprivation therapy (ADT) in localized and locally advanced prostate cancer (PCa), as a lower stage in PCa progression compared with metastatic PCa, is still unclear. This study compares the efficacy of castration alone with complete androgen blockade (CAB) as adjuvant ADT in patients with localized and locally advanced PCa undergoing radical prostatectomy (RP).Methods:Patients diagnosed with PCa, without lymph node or distant metastasis, who received RP in West China Hospital between January 2009 and April 2019, were enrolled in this study. We performed survival, multivariable Cox proportional hazard regression, and subgroup analyses.Results:A total of 262 patients were enrolled, including 107 patients who received castration alone and 155 patients who received CAB. The survival analysis revealed that there was no significant difference between the two groups (hazard ratios [HR]=1.07, 95% confidence intervals [95% CI]=0.60-1.90, P=0.8195). Moreover, the multivariable Cox model provided similarly negative results before and after adjustment for potential covariant. Similarly, there was no significant difference in the clinical recurrence between the two groups in both non-adjusted and adjusted models. Furthermore, our subgroup analysis showed that CAB achieved better biochemical recurrence (BCR) outcomes than medical castration alone as adjuvant ADT for locally advanced PCa (P for interaction=0.0247, HR=0.37, 95% CI=0.14-1.00, P=0.0497).Conclusion:Combined androgen blockade achieved better BCR outcomes compared with medical castration alone as adjuvant ADT for locally advanced PCa without lymph node metastasis.