简介：摘要：温度效应在桥梁结构的分析中有着重要作用。混凝土结构桥梁温度变化较小，在温度荷载下应力、变形并不显著。钢结构桥梁的温度变化较大，温度效应表现明显，因此对钢结构在温度荷载下的内力及变形进行分析十分关键。本文以钢箱梁系杆拱桥为依托，利用MIDAS Civil建立有限元模型，通过对钢箱梁系杆拱桥成桥后的温度效应进行分析，得到其在温度荷载下内力、变形的规律，对指导同类桥梁的施工有着较大的意义。

简介：摘 要: 现浇箱梁支架施工日益普遍，但对于高墩或水上箱梁现浇却存在施工和造价上的难点，为此，以重庆奉节互通F1匝道桥第三联高墩箱梁桥为例，运用有限元软件Midas Civil对桥墩横系梁进行临时预应力设计，即可在各个桥墩的横系梁上搭设钢管立柱到同一高程，再纵向搭设贝雷梁、支架以及模板进行箱梁现浇[1]。该施工设计很好的解决了高墩或水上施工的难点，降低了造价，同时为相似工程提供了一定的借鉴经验。

简介：摘 要：水平位移观测是形变观测的重要内容，假定坐标系因计算简单且无投影变形在测绘中具有较高的应用价值。针对假定坐标系在水平位移观测中研究较少的问题，本文首先对假定坐标系在工程应用中建立的方法进行探讨，论述了水平位移观测数据的处理方法。然后在满足测距和测角精度的前提下，通过实测实验验证了假定坐标系用于水平位移观测的可行性；在工作基点上用极坐标法对形变点进行观测，统计分析形变点位移量、累计位移量等形变位移相关数据，得出边坡位移形变缓慢的结论。最后对于缓慢位移的变形体，提出利用平面位移外符合精度中误差进行计算统计，从整体上分析各期位移对于首期数据的相对形变。为假定坐标系应用于水平位移观测提供一定的理论指导和实用参考价值。

简介：摘要：在经济社会发展的过程中，我国桥梁建设的质量也在不断完善与发展，很多新的结构形式开始出现在人们的眼前。在此基础上，为了确保桥梁结构的安全性与稳定性，要求技术人员必须要科学浇筑施工。鉴于此情况，本文将重点围绕墩柱含柱间系梁整体式浇筑施工工法进行研究，促进我国桥梁建筑行业的长远健康发展。

简介：摘要：上个世纪七十年代，第一座波形钢腹板箱梁桥——法国Cognac桥的成立，标志着波形钢腹板代替混凝土腹板成为了一种新的潮流。其应用由简支体系扩大到连续、刚构和斜拉桥体系，由等截面箱梁扩大到变截面箱梁，和预应力混凝土桥相比，波形钢腹板PC箱梁桥可降低造价约10%～30%。但随着跨径的增大，大跨径波形钢腹板梁桥腹板高度较大，腹板屈曲稳定问题突出。为解决大跨径波形钢腹板桥波形钢板屈曲失稳问题，提出一种主梁具有水平隔板的箱梁断面结构。

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简介：AbstractMucormycosis is a lethal human disease caused by fungi of the order Mucorales. Mucormycosis is caused by fungi mainly belonging to the genera Mucor, Rhizopus, and Lichtheimia, all of which belong to the order Mucorales. The number of individuals with mucormycosis-causing disorders has increased in recent years, hence, leading to the spread of mucormycosis. Throughout the coronavirus disease 2019 (COVID-19) pandemic, numerous cases of mucormycosis in COVID-19-infected patients have been reported worldwide, and the illness is now recognized as COVID-19-associated mucormycosis, with most of the cases being reported from India. Immunocompromised patients such as those with bone marrow sickness and uncontrolled diabetes are at a greater risk of developing mucormycosis. Genes, pathways, and other mechanisms have been studied in Mucorales, demonstrating a direct link between virulence and prospective therapeutic and diagnostic targets. This review discusses several proteins such as high-affinity iron permease (FTR1), calcineurin, spore coat protein (CotH), and ADP-ribosylation factors involved in the pathogenesis of mucormycosis that might prove to be viable target(s) for the development of novel diagnostic and therapeutic methods.

简介：摘要：商合杭高铁湖州制梁厂的移梁机通道内的移梁机反复行走，对通道内的淤泥质土反复碾压使存梁台座发生水平位移。根据现场情况采用高压旋喷桩处理移梁机地基。

简介：AbstractIn order to effectively implement the Tianjin Biosecurity Guidelines for Codes of Conduct for Scientists, biosecurity awareness-raising and education are essential because if these are not in place scientists will not understand the need for biosecurity codes of conduct. In an effort to assist in the implementation of the guidelines, a small-scale survey was carried out in early 2022 of biosecurity awareness-raising and education projects that have been developed over the last two decades to discover what resources and experience have been accumulated. It is argued that the survey demonstrates that much of what is needed to implement the guidelines effectively has been developed, but that there are specific deficiencies that need to be remedied quickly. In particular, an updated teaching resource covering the core issues related to the Biological and Toxin Weapons Convention (BTWC) and the problem of dual use in scientific research needs to be made widely available and translated into at least the six official United Nations (UN) languages. Additionally, more specialists from the Humanities with expertise in ethics need to become involved in biosecurity awareness-raising and education activities. While advantage should be taken now of the available national, regional and international networks of people involved in related activities, it is suggested that in the longer term cooperation in biosecurity awareness-raising and education will benefit from the development of an equivalent organisation to the International Nuclear Security Education Network (INSEN) organised through the International Atomic Energy Agency (IAEA).

简介：摘要目的探讨单核细胞型髓系来源抑制性细胞(M-MDSC)及相关细胞因子在急性冠状动脉综合征(ACS)患者外周血中的表达水平。方法采集2020年1月至2021年1月安徽省立医院心血管内科的62例初诊ACS患者、33例稳定性心绞痛(SAP)患者和40例健康对照者(HC)的外周血，采用流式细胞术检测M-MDSC的表达水平；检测粒细胞-巨噬细胞集落刺激因子(GM-CSF)和白细胞介素6(IL-6)水平；检测精氨酸酶-1(Arg-1)mRNA和诱导型一氧化氮合酶(iNOS)mRNA水平。分析M-MDSC在ACS、SAP和HC组中的表达水平，以及与GM-CSF、IL-6、Arg-1和iNOS水平的相关性。比较ACS患者治疗前后，M-MDSC及相关细胞因子的水平变化。结果与SAP组和HC组比较，ACS组患者外周血中M-MDSC、GM-CSF、IL-6和Arg-1 mRNA水平显著升高(均为P<0.01)。而急性ST段抬高型心肌梗死患者外周血中M-MDSC水平又较急性非ST段抬高型心肌梗死和不稳定性心绞痛患者显著升高(F＝28.502，P＝0.001)。M-MDSC水平与GM-CSF、IL-6和Arg-1 mRNA表达水平均呈正相关(均为P<0.01)。经治疗后，ACS患者外周血中M-MDSC、GM-CSF、IL-6和Arg-1 mRNA表达水平均明显下降(均为P<0.01)。结论M-MDSC在ACS患者外周血中表达水平显著升高，参与疾病的免疫调控，有望成为ACS调控的新靶点。

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简介：摘要：近几年，我们国家的客运专线获得了很大程度进步和发展，对铁路施工质量也有了更高的要求，所以，在实际开展铁路建设活动的期间，又出现了其他多元化的新型工艺和技术。当中预制箱梁主要通过流水线生产、工厂化作业的方式，进一步促进了建筑质量的提升和革新。预制箱梁的设置与建筑是针对延长结构使用寿命的前提下进行，在选取结构参数、建筑材料、施工技术等方面都充分考虑了耐久性的需求。基于此，笔者主要对梁场特大桥箱梁预制施工进行分析，具体内容如下。

简介：摘 要：随着我国道路桥梁建设的快速发展,预制小箱梁作为上承构件应用广泛,技术也相对成熟。但是,在施工过程中,受自然环境、操作人员的技术水平、项目管理水平等因素的影响,一些施工环节往往会出现一些问题,影响施工质量。328国道海姜段快速化改造工程主线桥上部结构主要为预应力混凝土组合箱梁，跨径以30m为主，梁高为1.6m。本文从台座施工、模板加工、钢筋制作、混凝土浇筑、预应力张拉等方面介绍了预制小箱梁施工工艺，阐述了预制小箱梁质量控制要点，可为同类工程施工提供借鉴和参考。

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简介：AbstractBackground:Zoonoses are public health threats that cause severe damage worldwide. Zoonoses constitute a key indicator of One Health (OH) and the OH approach is being applied for zoonosis control programmes of zoonotic diseases. In a very recent study, we developed an evaluation system for OH performance through the global OH index (GOHI). This study applied the GOHI to evaluate OH performance for zoonoses in sub-Saharan Africa.Methods:The framework for the OH index on zoonoses (OHIZ) was constructed including five indicators, 15 subindicators and 28 datasets. Publicly available data were referenced to generate the OHIZ database which included both qualitative and quantitative indicators for all sub-Sahara African countries (n = 48). The GOHI algorithm was used to estimate scores for OHIZ. Indicator weights were calculated by adopting the fuzzy analytical hierarchy process.Results:Overall, five indicators associated with weights were generated as follows: source of infection (23.70%), route of transmission (25.31%), targeted population (19.09%), capacity building (16.77%), and outcomes/case studies (15.13%). Following the indicators, a total of 37 sub-Sahara African countries aligned with OHIZ validation, while 11 territories were excluded for unfit or missing data. The OHIZ average score of sub-Saharan Africa was estimated at 53.67/100. The highest score was 71.99 from South Africa, while the lowest score was 40.51 from Benin. It is also worth mentioning that Sub-Sahara African countries had high performance in many subindicators associated with zoonoses, e.g., surveillance and response, vector and reservoir interventions, and natural protected areas, which suggests that this region had a certain capacity in control and prevention or responses to zoonotic events.Conclusions:This study reveals that it is possible to perform OH evaluation for zoonoses in sub-Saharan Africa by OHIZ. Findings from this study provide preliminary research information in advancing knowledge of the evidenced risks to strengthen strategies for effective control of zoonoses and to support the prevention of zoonotic events.

简介：摘要男性患儿，以急性耳痛、面神经麻痹为首发症状，行面神经减压术后面神经功能恢复。术后4个月病变累及颞骨及上颌骨，经颞骨肿块活检，病理确诊为髓系肉瘤，最终诊断为急性髓系白血病。经规律化疗3次后，颞骨MRI提示病变范围较前缩小，化疗4次后患儿行造血干细胞移植治疗，未见排异现象，半年后复查血常规及骨髓象已恢复正常。

简介：摘要：系杆拱桥体系受力结构一般较为复杂，在成桥阶段承载能力与桥梁施工过程中各技术要点控制是否标准有着直接关系；本文通过工程实例针对施工中的各个环节的一些要点进行分析，指出了目前大部分项目施工中不可避免的一些关键之处，以期为类似工程提供借鉴。

简介：摘要：教师的职责不仅是将知识与技能传授给学生，还有关注学生的情感发展、价值观形成等。“教书”与“育人”，缺一不可，有时候，后者似乎更为重要。面对幼儿园里几岁的小朋友，联想到北师大“学为人师，行为世范”的校训。在身教面前，言教的作用显得十分渺小。教师的身教，远比言教更为直观。教师的德行，会影响到幼儿一生的发展。所以，我们教师在幼儿面前，必须保持良好的形象，用实际行动显示人格魅力，在乡村教育中，做到情系留守，师德育春秋。