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500 个结果
  • 简介:PURPOSE:Vorinostat,ahistonedeacetylaseinhibitor,representsarationaltherapeutictargetinglioblastomamultiforme(GBM).PATIENTSANDMETHODS:PatientswithrecurrentGBMwhohadreceivedoneorfewerchemotherapyregimensforprogressivediseasewereeligible.

  • 标签: 化学化疗 临床 肿瘤 国外文摘
  • 简介:PURPOSE:ResistancetotemozolomidechemotherapyispartlymediatedbyO^6-methylguanine-DNAmethlytransferase(MGMT).ProtractedtreatmentwithtemozolomidepotentiallyovercomesMGMTresistanceandimprovesoutcome.WeconductedaphaseIIstudyofprotracteddailytemozolomideinadultswithlow-gradegliomas.EXPERIMENTALDESIGN:PatientswithnewlydiagnosedoligodendrogliomaoroligoastrocytomawithaMIB-1indexof〉5%orrecurrentlow-gradegliomasreceivedtemozolomide(75mg/m^2/dayin11-weekcyclesof7weekson/4weeksoff).Treatmentcontinuedforatotalofsixcyclesoruntiltumorprogressionorunacceptabletoxicity.Primaryendpointwasbestoverallresponserate;secondaryendpointswereprogression-freesurvival,overallsurvival,andtoxicity.

  • 标签: 肿瘤 MGMT DNA 临床 英外文摘
  • 简介:BACKGROUND:In2004,arandomisedphaseⅢtrialbytheEuropeanOrganisationforResearchandTreatmentofCancer(EORTC)andNationalCancerInstituteofCanadaClinicalTrialsGroup(NCIC)reportedimprovedmedianand2-yearsurvivalforpatientswithglioblastomatreatedwithconcomitantandadjuvanttemozolomideandradiotherapy.We'reportthefinalresultswithamedianfollow-upofmorethan5years.METHODS:Adultpatientswithnewlydiagnosedglioblastomawererandomlyassignedtoreceiveeitherstandardradiotherapyoridenticalradiotherapywithconcomitanttemozolomidefollowedbyuptosixcyclesofadjuvanttemozolomide.

  • 标签: GLIOBLASTOMA EUROPEAN 文摘 国外 CANADA
  • 简介:PURPOSE:Toevaluatethetoxicityandresponserateofbortezomibwithconcurrentradiotherapyandtemozolomideinthetreatmentofpatientswithcentralnervoussystemmalignancies.PATIENTSANDMETHODS:Thisopen-label,dose-escalation,PhaseⅠclinicalstudyevaluatedthesafetyofthreedoselevelsofintravenouslyadministeredbortezomib(0.7,1.0,and1.3mg/m(2)/dose)onDays1,4,8,and11ofa21-daycycle,inadditiontoconcurrentradiotherapyandtemozolomideatadailydoseof75mg/m(2)startingonDay1.Theprimaryendpointwasdose-limitingtoxicity,definedasanyGrade4-5toxicityorGrade3toxicitydirectlyat-tr/butabletoprotocoltreatment,requiringhospitalizationand/orradiotherapyinterruption.

  • 标签: BORTEZOMIB 文摘 国外 RATE was
  • 简介:PURPOSE:ThisphaseⅡtrialwasdesignedtodefinetheroleofO^6-benzylguanine(O^6-BG)inrestoringtemozolomidesensitivityinpatientswithrecurrentorprogressive,temozolomidc-resistantmalignantgliomaandtoevaluatethesafetyofadministeringO^6-BGincombinationwithtemozolomide.PATIENTSANDMETHODS:Patientswereaccruedintotwoindependentstrataonthebasisofhistology:glioblastomamultifonne(GBM)andaanaplasticglioma.BothtemozolomideandO6-BGwereadministeredonday1ofa28-daytreatmentcycle.Patientswereadministereda1-hourO^6-BGinfusionatadoseof120mg/m^2followedimmediatelybya48-hourinfusionatadoseof30mg/m^2/d.

  • 标签: GLIOBLASTOMA 文摘 国外 GLIOMA was
  • 简介:PURPOSE:Toevaluatesingle-agentactivityofbevacizumabinpatientswithrecurrentglioblastoma.PATIENTSANDMETH-ODS:Patientswithrecurrentglioblastomaweretreatedwithbevacizumab10mg/kgevery2weeks.Aftertumorprogression,patientswereimmediatelytreatedwithbevacizumabincombinationwithirinotecan340mg/m^2or125mg/m^2every2weeks,dependingonuseofenzyme-inducingantiepilepticdrugs.Completepatientevaluationswererepeatedevery4weeks.RESULTS:Forty-eightheavilypretreatedpatientswereaccruedtothisstudy.Thromboembolicevents(12.5%),hypertension(12.5%),hypophosphatemia(6%),andthrombocytopenia(6%)werethemostcommondrug-associatedadverseevents.Sixpatients(12.5%)wereremovedfromstudyfordrug-associatedtoxicity(fivethromboembolicevents,onebowelperforation).

  • 标签: 肿瘤 治疗 临床 国外文摘
  • 简介:PURPOSE:Fotemustineisanitrosoureacompoundusedforthetreatmentofmalignantgliomas,especiallyinFrance.Recently,anEORTC-NCICstudyhasshownthataconcomitantcombinationofradiotherapyplustemozolomide(anoralcytotoxicdrug)improvedsurvivalinglioblastomapatients.Wesetouttotestaconcurrentcombinationofradiotherapyandfotemustinefornewlymalignantgliomas.

  • 标签: 放射线疗法 EORTC-NCIC 神经脑质瘤 国外文摘
  • 简介:BACKGROUND:SupratentorialPNET(sPNET)arerareCNStumorsofembryonaloriginarisinginchildrenandadults.Thetreat-mentofsPNETforallagegroupsatourcancercenterhasbeenbasedonthemanagementofmedulloblastoma(MB),involvingneurosurgicaldebulkingfollowedbyeranio-spinalirradiation(CS1)andsystemicchemotherapy.METHODS:MedicalrecordswerereviewedtogatherdemographicandclinicaldataaboutallembryonalCNStumorsinchildrenandadultsfrom2001to2007.Tumorpathology,clinicalmanagementandsurvivaldatawerealsoassessed,particularlyasregardsthosepatientswhoreceivedthePackerchemotherapyregimenforeithersPNETorMB.

  • 标签: 肿瘤 CNS 临床 国外文摘
  • 简介:Glioblastomaisoneofthemostangiogenichumantumorsandcharacterizedbymicrovascularproliferations.Abetterunderstandingofglioblastomavasculatureisneededtooptimizeanti-angiogenictherapythathasshownapromisingbutincompleteefficacy.Thepresentstudyexamined48glioblastomasbyCD34endothelialmarkerperiodicacid-Schiff(PAS)dualstainingandfoundnon-endothelialcell-linedblood

  • 标签: 抗血管生成 胶质细胞 母细胞 治疗 体内 体外
  • 简介:Prophylacticantiepilepticdrugtherapyinpatientsundergoingsupratentorialmeningiomaresection:asystematicanalysisofefficacy.JNeurosurg.2011Jun3.[Epubaheadofprint]KomotarRJ,RaperDM,StarkeRM,IorgulescuJB,GutinPH.

  • 标签: 英文摘要 内容介绍 编辑工作 期刊
  • 简介:<正>InvitrobiologicaldosimetermodelingoftheglioblastomaresponsetoradiationdeliveredbytheGammaKnife.Laboratoryinvestigation.JNeurosurg.2010Dec;113Suppl:222-7.SmithR,SmithKA,BiggsCA,ScheckAC.Neuro-OncologyandNeurosurgeryResearch,BarrowNeurologicalInstitute,Phoenix,Arizona85013,USA.

  • 标签: Phoenix glioma Arizona delivered RELAPSE MEDIAN
  • 简介:Analysisoffactorsaffectingthelong-termfunctionaloutcomeofpatientswithskullbasemeningioma.JClinNeurosci.2011Jul;18(7):895-8.Epub2011May11.NakaoN,OhkawaT,MikiJ,NishibayahsiH,OguraM,UematsuY,ItalsuraT.

  • 标签: 英文摘要 内容介绍 编辑工作 期刊