简介：AIM:Toidentifythe100mostcitedpapersincataractsurgery,weperformedacomprehensivebibliometricanalysisbasingontheliteraturesearchontheThomsonReutersWebofKnowledge.METHODS:Thenumberofcitations,includingthetotalcitations,latest5ycitationsandaveragecitationnumberperyear(ACY),authorship,yearofpublication,majortopics,journalofpublication,countryandinstitutionoforiginofeachpaperwererecordedandthenanalyzed.Pearson'scorrelationanalysiswasconductedtoevaluatethecorrelationbetweenthepublishedyearandthenumberofcitations.Thecorrelationbetweenjournal'simpactfactor(IF)andnumberofcitationswasassessedaswell.RESULTS:ThemostcitedpaperwastheclassicpaperdonebytheEuropeanSocietyofCataract&RefractiveSurgeons(ESCRS)group.Thispaperfocusedonthetopicofendophthalmitis.NotonlythemostcitedpapersoriginatedfromtheUSA,butalsosomeAmericaninstitutionslikeJohnsHopkinsUniversity,HarvardMedicalSchool,etc.hadthemostcitations.Pearson'scorrelationanalysisindicatedthatthelatest5ycitationsandACYweresignificantlyrelatedwiththepublishedyear(5ycitations:r=0.615,P<0.001;ACY:r=0.657,P<0.001),whereasnoassociationbetweenthetotalnumberofcitationsandpublishedyearwasfound(r=0.045).Moreover,theIFsofjournalswerefoundtohavenosignificanteffectonthenumberoftotalcitations.CONCLUSION:Toourknowledge,thisisthefirststudyonthemostinfluentialpapersincataractsurgeryafteracomprehensiveresearchofrelevantliteratures.Thepresentworkmayprovideusconciseinformationconcerningthedevelopmenthistoryofcataractsurgeryoverthepast66y.

简介：目的对初期开展白内障超声乳化术100例（116眼）进行回顾性总结分析。方法观察白内障超声乳化术中、术后并发症的情况,探讨如何尽快掌握超声乳化技术。结果术中后囊破裂8眼,约占6.9%,晶体悬韧带部分离断3眼,约占2.6%;术后角膜病变32眼,约占27.6%,葡萄膜反应6眼,约占5.2%。结论初学白内障超声乳化术并发症较多,只要善于领悟和勤于实践,仍能掌握此项技术。

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简介：AIM:Todeterminetheclinicalfeatures,diagnosisandtreatmentoftheprimarySjogrensyndrome(SS)relatedopticneuritis.METHODS:Theclinicaldataof8patients(12eyes)withprimarySSrelatedopticneuritiswereanalyzedretrospectively.RESULTS:Eightof128consecutivepatientswithopticneuritisresultedfromvariedcausesfulfilledthediagnosticcriteriafortheprimarySS.Theypresentedinitiallywiththesignsandsymptomsofnon-specificopticneuritis,and5patientspresentingwithoutdrynessshowedachronicinflammationofsubmandibularglandorparotidgland,andlymphocyteinfiltrationwasdemonstratedbylabialglandbiopsyin2patients.Therewereserumpositivetitersforanti-SjogrensyndromeA(SSA)in7patientsandanti-SjogrensyndromeB(SSB)in8patients.Anti-aquaporin-4(AQP4)antibodywasnegativeinallthe8patients.Bothglucocorticoidsandimmunosuppressiveagentwereadministered,andvisualacuityelevatedin8eyes(66.7%),3patients(37.5%)recurredinthefollow-up.CONCLUSION:PrimarySSrelatedopticneuritisislesscommonandeasilymisdiagnosed.Theconventionaltherapiesforopticneuritiscouldnotcontroltherecurrence.

简介：Leber'scongenitalamaurosis(LCA)andrecentgenetherapyadvancementfortreatinginheritedretinopathieswereextensiveliteraturereviewedusingMEDLINE,PubMedandEMBASE.Adeno-associatedviralvectorswerethemostutilisedvectorsforoculargenetherapy.Conephotoreceptorcellsmightuseanalternatepathwaywhichwasnotreliantoftheretinalpigmentepithelium(RPE)derivedretinoidisomerohydrolase(RPE65)toaccessthe11-cisretinaldehydechromophore.Researcheffortsdedicatedontheprogressionofagene-basedtherapyforthetreatmentofLCA2.Suchgenetherapyapproacheswereextremelysuccessfulincanine,porcineandrodentLCA2models.TherecombinantAAV2.hRPE65v2adenoassociatedvectorcontainedtheRPE65cDNAandwasreplicationdeficient.ItsinvitroinjectionintargetcellsinducedRPE65proteinproduction.Thegenetherapytrialsthatweresofarconductedforinheritedretinopathieshavegeneratedpromisingresults.PhaseIclinicaltrialstocureLCAandchoroideremiademonstratedthatadeno-associatedviralvectorscontainingRPEgenesandphotoreceptorsrespectively,couldbesuccessfullyadministeredtoinheritedretinopathypatients.AphaseIIItrialispresentlyongoingandifsuccessful,itwillleadthewaytoadditionalgenetherapyattemptstocuremonogenic,inheritedretinopathies.

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简介：Aim:ToverifywhetherpartialintraoperativeTenon'scapsuleresection(PTCR)withadjunctiveMitomycinCiseffectiveindevelopingthin,avascularblebsineyesundergoingAhmedglaucomavalveinsertionandtoassesstheefficacyandsafetyofthisprocedure.Methods:ThisstudywasconductedinfourLatinAmericacountries(Argentina,Brazil,ColombiaandPeru).AhmedglaucomavalveimplantinsertionwithPTCR(groupA)andwithoutPCTR(groupB)wasperformedinneovascular

简介：白内障是最常见的致盲眼病之一。谷胱甘肽S转移酶（glutathioneS-transferases,GSTs）是典型的多功能酶,主要催化各种化学剂与谷胱甘肽结合。近些年的研究表明,GSTs有抗过氧化引起的白内障作用。GSTs表达水平的高低在白内障形成中有着重要的作用。我们将近年来GSTs与年龄相关性白内障的研究情况做一综述。

简介：AIMTo在Descemet的家根据厚度评估视觉尖酸和endothelial房间密度剥去自动化endothelialkeratoplasty(DSAEK)在外科以后的年。

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