简介：AIM:Toinvestigateandcomparetheefficacyoftwomachine-learningtechnologieswithdeep-learning(DL)andsupportvectormachine(SVM)forthedetectionofbranchretinalveinocclusion(BRVO)usingultrawide-fieldfundusimages.METHODS:Thisstudyincluded237imagesfrom236patientswithBRVOwithamean±standarddeviationofage66.3±10.6yand229imagesfrom176non-BRVOhealthysubjectswithameanageof64.9±9.4y.Trainingwasconductedusingadeepconvolutionalneuralnetworkusingultrawide-fieldfundusimagestoconstructtheDLmodel.Thesensitivity,specificity,positivepredictivevalue(PPV),negativepredictivevalue(NPV)andareaunderthecurve(AUC)werecalculatedtocomparethediagnosticabilitiesoftheDLandSVMmodels.RESULTS:FortheDLmodel,thesensitivity,specificity,PPV,NPVandAUCfordiagnosingBRVOwas94.0%(95%CI:93.8%-98.8%),97.0%(95%CI:89.7%-96.4%),96.5%(95%CI:94.3%-98.7%),93.2%(95%CI:90.5%-96.0%)and0.976(95%CI:0.960-0.993),respectively.Incontrast,fortheSVMmodel,thesevalueswere80.5%(95%CI:77.8%-87.9%),84.3%(95%CI:75.8%-86.1%),83.5%(95%CI:78.4%-88.6%),75.2%(95%CI:72.1%-78.3%)and0.857(95%CI:0.811-0.903),respectively.TheDLmodeloutperformedtheSVMmodelinalltheaforementionedparameters(P<0.001).CONCLUSION:TheseresultsindicatethatthecombinationoftheDLmodelandultrawide-fieldfundusophthalmoscopymaydistinguishbetweenhealthyandBRVOeyeswithahighlevelofaccuracy.TheproposedcombinationmaybeusedforautomaticallydiagnosingBRVOinpatientsresidinginremoteareaslackingaccesstoanophthalmicmedicalcenter.

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简介：AIM:Toinvestigatetheinfluencingfactorsofvisualfieldimprovementaftertrans-sphenoidalresectionofpituitarymacroadenomas.·METHODS:Thisretrospectivecohortstudyincluded201patients(366eyes)withvisualfielddefectinducedbypituitarymacroadenomas.Allofthemweretreatedwithtrans-sphenoidalsurgery.Ophthalmologicevaluation,best-correctedvisualacuity(BCVA),andvisualfieldexaminationwereperformedbeforeand3moaftersurgery.BCVA,visualfielddefectindexmeandeviation(MD),durationofsymptoms,age,sex,andvolumeoftumorswerecompared.Expressionofvascularendothelialgrowthfactor(VEGF)andKi-67oftumortissueweredetectedbyimmunohistochemicaltechnique.·RESULTS:Themeanageofpatientswas44.23±1.29y.Ninety-threepatientswerefemaleand108weremale.Themeantumorvolumewas14.36±6.23cm~3.Themeandurationofpreoperativesymptomswas11.50±0.88mo.MeanpreoperativeMDwas-17.50±0.82dB.MeanPreoperativevisualacuitywas0.64±0.04.Postoperativevisualfieldimprovedin270(73.77%)eyes,unchangedin96(26.23%)eyes.Multivariatelogisticregressiondisplayedthatthefactorsindependentlyinfluencingvisualfieldimprovementwereyoungage(OR=1.71,95%CI:1.325-2.387,P=0.013),lowpreoperativeMDabsolutevalue(OR=1.277,95%CI:1.205-1.355,P<0.001),smallvolumeoftumor(OR=1.458,95%CI:1.060-4.289,P<0.001),lowexpressionofVEGFintumortissue(OR=1.554,95%CI:1.089-2.457,P=0.022),andlowexpressionofKi-67intumortissue(OR=1.552,95%CI:1.161-2.847,P=0.026).·CONCLUSION:Afterpituitarymacroadenomastranssphenoidalresection,theindependentinfluencingfactorsofthevisualfieldsrecoverywerelowpreoperativeMDabsolutevalue,youngage,smallvolumeoftumor,andexpressionlevelsofVEGF/Ki-67.