学科分类
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2 个结果
  • 简介:AIM:Toconductasystematicreviewofthepublishedepidemiologicalstudiesinvestigatingtheassociationoftheinteractionsbetweengenevariantsanddietaryintakewithgastriccancerrisk.METHODS:AliteraturesearchwasconductedinPubMed,EMBASE,andMEDLINEforarticlespublishedbetweenJanuary2000andJuly2013,and38studieswereidentified.Previousstudiesincludedvariousdietaryfactors(e.g.,fruitsandvegetables,soybeanproducts,salt,meat,andalcohol)andgeneticvariantsthatareinvolvedinvariousmetabolicpathways.RESULTS:Studiessuggestthatindividualswhocarryhigh-riskgeneticvariantsanddemonstrateparticulardietaryhabitsmayhaveanincreasedriskofgastriccancercomparedwiththosewhodonotcarryhigh-riskgeneticvariants.Distinctivedietarypatternsandvariationsinthefrequencyofgeneticvariantsmayexplainthehigherincidenceofgastriccancerinaparticularregion.However,mostpreviousstudieshavelimitations,suchasasmallsamplesizeandaretrospectivecasecontroldesign.Inaddition,paststudieshavebeenunabletoelucidatethespecificmechanismingene-dietinteractionassociatedwithgastriccarcinogenesis.CONCLUSION:Additionallargeprospectiveepidemiologicalandexperimentalstudiesarerequiredtoidentifythegene-dietmetabolicpathwaysrelatedtogastriccancersusceptibility.

  • 标签: GASTRIC CANCER GENE DIET INTERACTION
  • 简介:瞄准:评估与hemihepatic经历hepatectomy的病人的临床的结果脉管的吸藏(HHO)与全部的肝的流入吸藏(THO)相比。方法:比较hemihepatic的使随机化的控制试用(RCT)脉管的吸藏和全部的肝的流入吸藏被系统的文学搜索包括。二个作者独立地为包括估计了试用并且提取了数据。元分析被进行基于aspartateaminotransferase(著名计算机生产厂商)和丙氨酸aminotransferase(中高音)的层次估计血损失,输送要求,和肝损害。固定效果模型或随机的效果模型被使用。结果:包括338个病人的四RCT满足了predened包括标准。167个病人的一个总数与THO被对待并且171与HHO。著名计算机生产厂商的元分析与加权的吝啬的差别(WMD)在THO组在手术后的白天铺平1显示的高水平342.27;95%信心间隔(CI)217.28-467.26;P=0.00001;I2=16%。元分析没在血损失上显示出THO组和HHO组之间的重要差别,输送要求,死亡,病态,操作时间,ischemic持续时间,医院停留,在手术后的白天的中高音层次1,3和7并且在手术后的白天的著名计算机生产厂商层次3和7。结论:Hemihepatic脉管的吸藏不把令人满意的利益提供给经历肝的切除术的病人。然而,他们在肝切除术以后有更少的肝损害。

  • 标签: 闭塞系统 肝切除 随机对照试验 随机效应模型 固定效应模型 Meta分析