简介：

简介：

简介：ObjectDiastolicfunction’sassessmentisvitalinordertoproduceinformationrelevanttopatients’functionalclass,managementandprognosis.Wesoughttoinvestigatediastolicdysfunctioninessentialhypertension(EH)withorwithoutcoronaryheartdisease(CAD)usingcolorM-modeDopplerechocardiographyandtostudytherelationbetweendiastolicdysfunctionandleftventricularmassindex(LVMI)andgeometryofLV,andtodemonstratepartlythecauseofincreasedcardiovascularriskofanechocardiographicpatternofLVgeometry.Methods36normalsubjects(GroupⅠ)and107patientswithessentialhypertension(GroupⅡ)werestudiedusingcolorM-modeDopplerechocardiography.FourdifferentLVanatomicadaptationtohypertensionwerei-dentifiedbycategorizingpatientsaccordingtovaluesofend-diastolicrelativewallthickness(RWT)andLVMI.Wemeasuredtherateofpropagationofpeakearlyfillingflowvelocity(Vp),timedelay(TD)ofthepeakearlyfillingflowvelocityfrommitral

简介：ObjectivesToelucidatethepotentialroleofcytokinesinthepathogenesisofcoronaryheartdisease(CHD).MethodsTNF-αandIFN-γactivity,IL-8levelsofplasmaandsupernatantsweremeasuredin62patientswithCHDand30healthcontrolsbymethodsofdirectcytotoxicityassay,cytopathiceffectinhibitiontestandELISArespectively.ResultsBothTNF-αactivityandIL-8levelsofplasmainCHDpatientswerehigherandIFN-γactivityofsupernatantsinCHDpatientswerelowerthanthoseofhealthycontrols(P＜0.001),TherehavesignificantdifferencesbetweenhealthycontrolsandthesubgroupsofCHD(P＜0.01).IL-8levelsofplasmaincreasedwiththeadvancingofthediseaseandtherehaveobviousdifferencesamongsubgroupsoftheillness(P＜0.05).TNF-αactivityofplasmainstableanginapectoris(SAP)subgroupwaslowerthanthoseofunstableanginapectoris(UAP)andacutemyocardialinfarction(AMI)subgroups,thedifferencesbetweenSAPandUAPorAMIweresignificant(P＜0.05),ButtherehavenosignificantdifferencesbetweenUAPandAMI(P＞0.05).However,IFN-γactivityofsupernatantsshowednodifferenceamonganysubgroups.ConclusionstherehavecloserelationsbetweenTNF-α,IFN-γ,IL-8andCHD.