简介:Dearcolleaguesanddistinguishedguests:Onbehalfoftheorganizingcommitteeofthe11thSouthChinaInternationalCongressofCardiology(SCC),itisourdistincthonortoinviteyoutoattendtheSCCCongress,whichisgoingtobeheldon9-12April,2009atDongfangHotel,Guangzhou,China.
简介:TheorganizersofSCCwelcomethesubmissionofabstracts.Submissionscoveringallaspectsofcardiovasculardiseasearewelcome.Allacceptedabstractswillbepublishedinsupplement(s)oftheSouthChinaJournalofCardiology.Theexcellentabstractwillbeselectedforpresentationatthesessiononthe11thSCCandrewarded$1000-$5000.Beawarethatyouracceptedabstract(s)willbepublishedandyourcopyrighttransferredtoSCConpublication.
简介:ObjectivesToinvestigatetheeffectofGαq/11signalingpathwayandATP-sensitivepotassiumchannel(KATPchannel)onischemicpreconditioning(IPC)protectioninrathearts.MethodsTwoseriesofexperimentswereperformedinWistarrathearts.Inthefirstseriesofexperiment,ischemicpreconditioningwasinducedbyleftanteriordescendingocclusion(three,5minepisodesseparatedby5minofreperfusion),ischemia-reperfusioninjurywasinducedby30mincoronaryarteryocclusionfollowedby90minreperfusion.Hemodynamics,infarctsizeandscoresofventriculararrhythmiasweremeasured.TheexpressionofGαq/11proteinintheheartwasmeasuredbyWesternblotanalysisinthesecondseries.ResultsIschemicpreconditioningratsshoweddecreasedinfarctsizeandscoresofventriculararrhythmiavsnon-IPcontrolrats.TheeffectofIPCwassignificantlyattenuatedbyglibenclamide(1mg/kg,ip),anonselectiveKATPchannelinhibitor.IPCcausedasignificantincreaseintheexpressionofGαq/11protein.ConclusionsActivationsofGαq/11signalpathwayandKATPchannelplayedsignificantrolesintheclassicalcardioprotectionofischemicprecon-ditioningratheartandmightbeanimportantmechanismofsignaltransductionpathwayduringtheischemicpreconditioning.
简介:目的对2例老年C型尼曼-皮克病(Niemann-PickdiseasetypeC,NPC)患者及家系的NPCI和NPC2基因进行测序,分析基因型与表型关系。方法采集2例NPC患者及家系外周血,提取基因组DNA,进行引物设计扩增,直接基因测序检测。结果2例患者在NPCI基因6号外显子发现1个杂合子位点A644G(H215R),导致第215位氨基酸由His突变为Arg;18号外显子发现1个杂合子位点N931N(C2793T),氨基酸编码没有改变;2例家系其他成员未发现异常。结论NPC患者具有典型NPC临床特征,在基因水平上发现,相关基因突变位点或新的突变位点,但家系基因特征不明显。因此,对于老年NPC患者或存在其他致病因素。