简介:【摘要】目的 分析对体检者实施慢病风险评估及健康管理的效果。方法 抽取 2019年 1月至 2019年 12月间我院受检者 226名作为此次的观察对象,并将其随机分成两组,其中 113名纳入对照组,接受慢病风险评估 +自我管理,其余 113名纳入实验组,接受慢病风险评估 +健康管理。分析管理前、后的不良生活方式改善情况以及慢性病发病情况。结果 管理前,两组的不良生活方式对比无统计学意义,管理后,两组的不良生活方式改善情况差异明显( p<0.05);管理前,两组的慢性病发病率比较无明显差异( p>0.05),管理后,两组的慢性病发生率比较差异明显( p<0.05)。结论 对体检者实施慢病风险评估 +健康管理的效果明显,值得推广应用。
简介:摘要:糖尿病是临床常见的基础内分泌疾病,病情迁延日久,易并发其他疾病,而糖尿病肾病(Diabetic nephropathy,DN)是其最常见的微血管并发症之一。若病情控制不佳,DN后期患者会出现终末期肾衰竭,更有甚者会导致患者死亡。肾小球系膜细胞(glomerular mesangial cells,MC)是一种肾小球固有细胞,在各种病理因素作用下,MC被激活引起细胞增殖、分裂,分泌大量细胞外基质,导致肾小球炎症和硬化,是糖尿病进展到糖尿病肾病的重要标志。研究表明,DN发生发展与肾小球系膜细胞自噬缺陷相关。DN发生时肾组织中存在蛋白质损伤,而自噬途径是细胞内损伤蛋白质清除的主要途径之一。本文主要介绍肾小球系膜细胞自噬缺陷对糖尿病肾病的影响。
简介: [摘要 ] 目的 研究应用小剂量胰岛素持续滴注治疗小儿糖尿病酮症酸中毒的临床效果。方法 该次纳入 2019年 1—12月收治的 72例糖尿病酮症酸中毒患儿展开研究,按照随机数字表法分为两组,在常规治疗的基础上,对照组 36例采用常规剂量胰岛素治疗,观察组 36例采用小剂量胰岛素持续滴注治疗。将两组的临床相关指标、临床效果、住院时间、低血糖发生率进行比对。结果 观察组糖尿病酮症酸中毒患儿的尿酮体转阴时间、临床症状消失时间及住院时间短于对照组,血糖下降速度慢于对照组,空腹血糖水平、餐后 2 h血糖水平、低血糖发生率均低于对照组,临床总有效率高于对照组,差异有统计学意义( P<0.05)。结论 对糖尿病酮症酸中毒患儿采用小剂量胰岛素持续滴注治疗能够起到平稳降糖、改善临床症状的作用,还可减少低血糖的发生,具有较高的安全性。 [关键词 ] 小儿糖尿病酮症酸中毒 ;小剂量胰岛素 ;滴注 [Abstract] Objective To study the clinical effect of continuous infusion of low-dose insulin in the treatment of diabetic ketoacidosis in children. Methods 72 children with diabetic ketoacidosis admitted from January to December 2019 were enrolled in the study, and they were divided into two groups according to the random number table method. On the basis of conventional treatment, 36 cases in the control group were treated with conventional dose of insulin, and 36 cases in the observation group were treated with continuous infusion of low-dose insulin. The clinical related indexes, clinical effects, length of stay and incidence of hypoglycemia were compared between the two groups. Results the urine ketone body negative turning time, clinical symptoms disappearance time and hospitalization time of the observation group were shorter than those of the control group, the blood glucose decreased slower than the control group, the fasting blood glucose level, 2 h postprandial blood glucose level, hypoglycemia incidence rate of the observation group were lower than those of the control group, the clinical total effective rate was higher than that of the control group, the difference was statistically significant (P < 0.05). Conclusion continuous infusion of low-dose insulin in children with diabetic ketoacidosis can play a stable role in reducing blood sugar, improving clinical symptoms, and reducing the incidence of hypoglycemia, with high safety.