简介:Objective:Tostudytheeffectofthreedifferentmethodssuchasmedicine,acupunctureandlaseracupunctureonthelevelsofinterleukin2(IL-2),interleukin6(IL-6)andtransforminggrowthfactor-β1(TGF-β1)inrat’sserumwithchronicatrophicgastritis.Methods:9ratswererandomlyselectedfrom60ratsasnormalcontrolgroup,andtheotherratswereusedtoreplicatetheanimalmodelofchronicatrophicgastritiswithcomprehensivemethod,5ratswererandomlyinspectedatthe8thweekintheprocessofcreatingmodelforgastricmucosapathologicalexamination;whengastricmucosashowsCAGsymptomssuchasvariousdegreeofcongestion,bleeding,atrophy,metaplasia,themodelratswererandomlydividedintomodelgroup,medicinegroup,acupuncturegroupandlaseracupuncturegroup.TheratsofmedicinegroupwerechronicallyadministeredwithyanshenjianweicapsuleandKangfuxinLiquid;thegroupsofacupunctureandlaseracupunctureselectedZusanliacupunctureasacupuncturepoints,afterthetreatmentfor14d,bloodwasremoved,doubleantibodysandwichenzymelinkedimmunosorbentassay(ELISA)wasusedtodetectthelevelsofIL-2,IL-6andTGF-β1inserum.Results:Comparedwithnormalgroup,thecontentsofIL-2,IL-6andTGF-β1inserumofmodelratsincreased(P<0.05orP<0.01).Medicine,acupunctureandlaseracupuncturecouldreducethecontentsofIL-2,IL-6andTGF-β1,IL-2inserumofthemedicinegroupandlaseracupuncturegroupwassignificantlydecreased(P<0.05);IL-6inacupuncturegroupandlaseracupuncturegroupweresignificantlydecreased(P<0.05orP<0.01);andthemostsignificantislaseracupuncturegroup(P<0.01).Medicine,acupunctureandlaseracupuncturecouldsignificantlyreduceTGF-β1contentinserum(P<0.05orP<0.01),andtheparticularlysignificantwaslaseracupuncture(P<0.01).Conclusion:Laseracupuncturehasthefunctionofreducingtheinflammatoryresponseandadjustingimmunefunction.ItcaneffectivelyreducetheexpressionlevelofIL-2,IL-6andTGF-β1inserumofratswithchronicat
简介:目的探讨急性髓系白血病(AML)患者MDR1和Nrf2基因表达水平及其临床意义。方法选择2011年10月至2014年1月南方医科大学南方医院血液科110例初治AML患者,其中男性66例,女性44例;年龄14~77岁,中位年龄36岁。通过实时荧光定量聚合酶链反应(PCR)方法联合检测患者MDR1和Nrf2基因的表达水平,分析其表达水平与疾病特征及临床疗效之间的关系。结果以110例初治AML患者MDR1和Nrf2基因表达量的中位数为分界点,将患者分别分为MDR1基因低表达组和MDR1基因高表达组及Nrf2基因低表达组和Nrf2基因高表达组各55例,而初治AML患者MDR1和Nrf2基因表达水平在不同分层的年龄、性别、法国(France)、美国(American)和英国(Britain)(FAB)分型、外周血象、骨髓原始细胞比例、遗传学危险度分层、免疫分型CD34表达间差异无统计学意义(P〉0.05)。MDR1基因低表达组完全缓解(CR)率和总生存(OS)率均显著高于MDR1基因高表达组(P=0.032、0.045),而Nrf2基因低表达组和Nrf2基因高表达组CR率和OS率差异无统计学意义(P〉0.05)。在MDR1基因低表达组患者中Nrf2基因表达水平高、低两组患者CR率及OS率差异均无统计学意义(P〉0.05)。但在MDR1基因高表达组患者中Nrf2基因高表达组患者CR率和OS率皆优于Nrf2基因低表达组患者(P=0.007和P=0.001)。结论MDR1基因是AML预后差的指标之一,Nrf2基因不同表达水平患者的危险度分层、疗效、预后差异均无统计学意义;但在MDR1基因高表达组患者中Nrf2基因高表达可能是预后好的指标。
简介:目的分析乳腺癌钼靶X射线影像学征象,探讨其对乳腺癌的诊断价值。方法选择2005年2月-2008年2月308例乳腺病变患者,均为女性,年龄12-85岁,平均年龄48.5岁。其中经手术病理证实的乳腺癌患者287例。对此病例钼靶X射线征象进行回顾性分析。结果287例乳腺癌中病理浸润性导管癌213例,占74.22%;导管原位癌30例,占10.45%;黏液腺癌15例,占5.23%;髓样癌17例,占5.92%;浸润性小叶癌12例,占4.18%。钼靶X射线影像特征为肿块影的243例,占84.67%(243/287),部分有毛刺样改变或呈分叶状;钙化124例,占43.21%(124/287),42例仅有细小点状钙化;结构紊乱75例,占26.13%(75/287);乳头内陷30例,占10.45%(30/287);厚皮征38例,占13.24%(38/287)。结论临床上根据病史、体检,并结合乳腺钼靶X射线摄影的多种X射线征象对乳腺癌的早期诊断具有重要价值。
简介:Inthispaper,weproposeamethodtoimproveanti-radiationcapabilitybycoatingheavymetalX-rayprotectionglasswithcompoundphotoniccrystallayers,basedontheuniquepropertyofphotoniccrystalthatlightcannotbepropagatedwithintherangeofbandgaps.Usingtheplanewaveexpansionmethod,wemadeatheoreticalstudyofparametersaffectingthebandgapstructuresofone-dimensionalphotoniccrystals.Basedonthefindings,wechoseappropriatematerialsandcompoundstructureofphotoniccrystalsoastogethighX-rayreflectioncoatingphotoniccrystallayers.Bythismethod,thereflectionratewithinX-raywavelengthcanreachthemaximumvalueof100%,andtheaveragevalueofover90%.Evenlow-costheavymetalX-rayprotectionglassofabsorptioncoefficientvaluecanachievethedesiredeffect.Thus,thismethodgreatlydecreasestheanti-radiationrequirementsofheavyX-rayprotectionglass.
简介:LFA-1andMac-1,twoβ2integrinmembersconstitutivelyexpressedonneutrophils,mediateleukocyterecruitmentcascadebybindingtothesameligandofICAM-1.TheslowrollingandfirmadhesionofleukocytesrelyonLFA-1whilethecellcrawlingisdependentonMac-1.Wehypothesizedthattheirdistinctroleswerelikelyattributedtothedifferencesinthebindingkineticsorinthediverseresponsesofoutside-inandinside-outsignaling.Inthisstudy,wecomparedtheICAM-1bindingfeaturesbetweensolubleormembrane-expressedLFA-1andMac-1withdifferentaffinityconformationsusingopticaltraptechnique.Ourdataindicatethattheaffinityup-regulationfromwidetype(WT)tohighaffinity(HA)isoff-ratedependentforLFA-1buton-ratedependentforMac-1.Thestructuralbasesofthisnewfindingwerefoundtobeconsistentwithourprevioussimulations.Theseresultsfurtheredourunderstandingontheirfunctiondifferencesundershearflow.
简介:Inthisarticle,wepresentanalternativederivationforBronnikov’sreconstructionalgorithminX-rayphasecontrasttomographywithholographicmeasurements.Atwo-stepmethodwasusedinthealternativederivation.ThephaseshiftinducedbytheobjectwasobtainedbyFouriertransformandtherealpartofthecomplexrefractiveindexoftheobjectwasretrievedbyapplyingtheconventionalfilteredbackprojectionmethod.Thealternativederivationprovidesaneasierwaytounderstandthereconstructionformula.
简介:MAY28,2009--GEHealthcare(ChalfontSt.Giles,UK),agloballeaderinhealthcaresolutionsandLightLabImagingInc.(Westford,MA),amarketleaderinopticalimaging,haveannouncedacollaborationthatenablesimprovedworkflowbetweenGEHealthcare'sInnovacardiovascularX-raysystemandLightLab'sC7-XRopticalcoherencetomography(OCT)system.BoththeC7-XRandInnovasystems
简介:目的探讨计算机X射线摄影(CR)在静脉肾盂造影应用中以满足图像诊断质量和X射线曝光参数(kVp、mAs)的优化组合,使X射线剂量控制在最低,降低被检者的有害X射线辐射量。方法对3组不同体型厚度(18cm、22cm、26cm)的被检者,对每组分别以常规摄影条件,增加kVp、降低mAs进行摄影。以kVp与mAs组合图像质量完全满足诊断要求,剂量最低的参数作为最优参考曝光参数。用体模替代3种被检者体型厚度,用同样摄影曝光参数,分别测量体表、体后及有关被检者器官组织的吸收X射线剂量。结果与常规摄影相比,被检者的X射线吸收剂量平均降低了31.97%,面积乘积剂量平均降低了34.57%,有效剂量降低了33.98%。结论在静脉肾盂造影中用CR成像技术与投照参数优化组合,对降低被检者的X射线吸收剂量是行之有效的,为其他投照部位用CR或数字X射线摄影(DR)数字成像参数优化组合研究提供了指导性的方法,有一定的临床应用价值。
简介:传统x射线对软组织的成像是目前的技术弱点。硬x射线是用x射线穿过物体后,x射线的相位改变作为成像因子,它对软组织有较好的成像效果。本课题用硬x射线成像对肝肿瘤组织和胃肿瘤组织进行成像。将25lμHCT-8人结肠癌细胞移植在裸鼠肝脏上,分别在3d、4d、5d和6d处死裸鼠,取出肝脏。用同样的方法培养裸鼠早期胃肿瘤,并在3d和4d后取出裸鼠胃。对标本进行硬x射线的成像方法即类同轴全息法成像。硬x射线可以对裸鼠肝肿瘤和胃肿瘤进行成像,并且图像分辨率在微米数量级,培养6d的肝肿瘤可见肿瘤组织。也可清晰观察到3d和4d的胃肿瘤。硬x射线成像原理是一个用相位改变因子成像的模式,它的成像对微小物体有着微米级的图像分辨率,是影像学从宏观成像到微观成像的关键,对发现早期的病变组织有明显的优势。
简介:Phasecontrastimagingtechniquehasbeenimprovedpromptlyinrecentyears.Amongthesetechniquesin-linephase-contrastimagingiswidelyused.Variousalgorithmsforin-linephaseretrievalhavebeenproposedsofarsuchasTIE(transportofintensityequation),CTF(contrasttransferfunction),firstborn-approximations,GSF(Gerchberg-Saxton-Fienup),etc.Bronnikov'salgorithm(BA)isatypeoflinearalgorithmthatissimpleandefficient.Butitcanonlybeusedwithoutabsorptionsituations.Inthispaper,animprovedalgorithmbasedonBAwaspresented.TheapproachaddsΔφ(x,y)tothephasemapφ_b(x,y)retrievedbyBAtomakethereconstructedphasemapmoreprecise.Further,theapproachwasevaluatedonsimulatedimagesandconfirmedtobeaccurateathigherabsorptionrates.
简介:目的探讨直接数字化X射线摄影(DR)在患儿腹部检查中的应用价值。方法选择行DR腹部检查的650例患儿,其中男性356例,女性294例,年龄12h~10岁。对其腹部平片的质量及病变进行分析。结果在650张DR腹部平片中,有595张甲级片(占91.54%),55张乙级片(占8.46%),0张丙级片。病变显示情况:通过DR数字化调节,不典型小气液平影101例,急性假性肠梗阻87例;机械性肠梗阻35例。肠套叠21例;小肠疝气8例。消化道穿孔13例。食管裂孔疝2例。膈膨升48例。胃扩张5例。先天性脐膨出2例。坏死性小肠结肠炎19例。腹腔积液13例。腹膜炎2例。消化道异物151例。消化道畸形57例。脊柱发育畸形69例。泌尿生殖系异常影像5例。膈下区肺炎、盘状肺不张3例,膈下肋骨骨折9例。结论腹部DR平片是大部分腹部疾病的首选检查方法,只要腹部摄片质量优良,诊断医师充分利用DR的优势,认真仔细观察分析后,对腹部各脏器疾病尤其是空腔脏器的疾病就能做出正确诊断,为临床提供十分重要的诊断依据。
简介:Curcumin,adietaryphytochemical,exhibitsmultifunctionalnaturalproductwithregulatoryeffectsoninflammation.However,thepoorbioavailabilitylimitsitsclinicalapplications.Thus,wedesignedandsynthesizedanovelmonocarbonylanalogueofcurcuminB7andtheirinhibitionagainstmonocytechemotacticprotein-1(MCP-1)andinterleukin-8(IL-8)releasewasevaluatedinH2O2-stimulatedhumanvascularendothelialcells(ECs)inadose-responsivemanner,whileexhibitingnocytotoxicityinECs.Takentogether,theseinsightsonthenovelcompoundB7mayserveaspotentialagentsforthetreatmentofatherosclerosis.