简介:InordertorevealvariationandrevolutionofNPgenesofhumanavianH_5N_1influenzavirusstrains,theNPgeneofahumanavianH_5N_1influenzavirusstraininGuangdongwassequencedandtheglobalNPgenesofstrainswereretrieved.ThesequenceswereanalyzedbyDNAStar5.0,andtheevolu-tionaryspeedwasstudiedwithreferencetotheepidemiologicaldata.ItwasfoundthatNPgenesof45strainsduring1997-2006werehomologicallyclassifiedintothreegroups:strainsin1997-1998,strainsin2004-2005andstrainsfrom2003to2006.Therewere35substitutionsinNPsinallstrainsaccountingforaratioof7.03%(35/498).Anadditionalglycoproteindomain(NGT_(430-432))wasfoundinNPgenesinthestrainsof2003-2006,themutationofN_(370)SinGD-01-06resultedinoccurrenceofonemoreglyco-proteindomain(NES_(368-370)).Inthesynonymousvariation,K_svaluesinNPwere2.03×10~(-5)-2.55×10~(-5)Nt/dandK_avaluesinNPwere1.58×10(-6)-3.10×10~(-6)Nt/d.Theredidn′texistobviouslyselectivepres-sure.Anadditionalglycoproteindomainineverystrainof2003-2006andonemoreinstrainGD-01-06mightchangetheantigenicityofhumanavianH_6N_1influenzavirus.ThevariationonhumanavianH_5N_1influenzastrainsoccurredfrequentlyinthenaturalworld,whichwouldresultinhighprobabilityofhu-man-humantransmissionalongwiththenaturalevolutionofthevirus.
简介:摘要:在新冠肺炎抗疫过程中,为切断传播途径,避免交叉感染,保护医护人员自身安全,医护人员在接触确诊患者或疑似患者时,必须佩戴医用N95口罩,做好严格的隔离防护。因N95口罩密闭性能良好,紧贴面部,且医护人员佩戴时间一般较长,导致面部压力性损伤时有发生。为预防面部压力性损伤的发生,特提出几种预防小技巧。本文中4种方法各有优势,其中赛肤润液体敷料成本虽高,但使用方法简单,对皮肤刺激性相对小,预防压力性损伤效果好,容易被一线医护人员所接受。
简介:【摘要】2020年初,在湖北武汉爆发了新型冠状病毒感染的肺炎疫情,全国30个省启动了重大突发公共卫生事件一级响应。绵竹市为进一步做好全市医疗卫生应对呼吸道相关重大传染病的防控工作,提高对新冠肺炎防治水平和应对能力,切实有效地防止新冠肺炎疫情的扩散蔓延,提出了建立疫情防控的“1+6+N”三级医疗救治体系。本文以孝德卫生院围绕“1+6+N”开展的系列工作为例,阐述了“1+6+N”体系在疫情防控中的作用。