简介：Theexpressedproteinswereextractedfromhumanbenignprostatichyperplastictissuesobtainedwithtransurethralresectionoftheprostatebeforeandaftertheirirradiationwithradioactivenuclide.Theproteinswereseparatedbytwo-dimensionalgelelectrophoresisandanalyzedbymassspectrometry.Fourproteinsweredifferentiallyexpressedandwereidentifiedwithadatabasesearch.ThreewereassociatedwiththeregulationofcellmotionandonewaslactatedehydrogenaseB,whichplaysanimportantroleintheprocessofcellenergymetabolismandcellstatechangesintissue.Thecomparativeproteomicanalysisindicatesthatafterirradiationwithradioactivenuclide,changesoccurinhumanbenignprostatichyperplasticcells,andassociatedproteinsareexpressed.Analysisoftheseproteinsshouldhelptoidentifythemechanisminvolvedwhenhumanprostatichyperplasiaistreatedbyirradiationwithradioactivenuclide.