简介:Thereisalargegapbetweenthenumberofmembraneprotein(MP)sequencesandthatoftheirdecoded3Dstructures,especiallyhigh-resolutionstructures,duetodifficultiesincrystalpreparationofMPs.However,detailedknowledgeofthe3DstructureisrequiredforthefundamentalunderstandingofthefunctionofanMPandtheinteractionsbetweentheproteinanditsinhibitorsoractivators.Inthispaper,somecomputationalapproachesthathavebeenusedtopredictMPstructuresarediscussedandcompared.