简介：AIM:Toinvestigateandcomparethecytopathologicalandclinicaleffectsofamnioticmembranetransplantation(AMT)andoralmucosalmembranetransplantation(OMMT)insocketcontraction.METHODS:Twelvepatientswhocouldnotbefittedwithocularprosthesisduetosocketcontracturewereincludedinthisstudy.SevenpatientsunderwentAMTand5patientsunderwentOMMT.Thirteenpatientswhohadhealthysocketswereincludedascontrolgroup.Depthofinferiorfornix,degreeofinflammation,extentofthesocketcontractureandsocketvolumeweremeasuredinthepreoperativeperiodandatsixthandtwelfthweekspostoperatively.Impressioncytologyofconjunctivalfornicesandteartransforminggrowthfactorbeta-1(TGFβ1)levelsweredetermined.RESULTS:IntheAMTgroup,socketvolumeandlowerfornixdepthvaluesweresignificantlyhigher(P=0.030andP=0.004respectively)andinflammationlevelsandimpressioncytologystages(P=0.037andP=0.022respectively)weresignificantlylowerinpostoperativeperiodcomparedtopreoperativeperiod.IntheOMMTgroup,nostatisticaldifferenceswerefoundintermsofclinicalparameters,inflammationlevelsandimpressioncytologystagesofpreoperativeversuspostoperativevalues.PreoperativetearTGFβ1levelswerehigherinAMTandOMMTgroupscomparedtothecontrolgroup(25.5ng/mL,26.3ng/mLand21.7ng/mLrespectively).DecreasedtearTGFβ1levelswereobservedinboththeAMTandOMMTgroupspostoperatively(mediandecreasevalue=2.1ng/mLand2.7ng/mLrespectively).CONCLUSION:AMTisassociatedwithpostoperativeimprovementininferiorfornixdepth,socketvolume,inflammationandimpressioncytologylevelsandmaybeamoreproperalternativemethodthanOMMTinthemanagementofsocketcontracture.