简介：Objective:Toobservetheexpressionoflamininandfibronectininalkali-burnedcorneasinrats.Methods:Atotalof18normalWistarratswererandomlydividedinto6groups(n=3ineachgroup).Foreachrat,oneeyewasinjuredbyalkaliburn,theotheronewastakenasthenormalcontrol.Thenallthecorneasweresurgicallyremovedandtheexpressionoflamininandfibronectinwasobservedwithimmunohistochemistryrespectivelyat7hours,1day,3days,7days,14daysand28daysafteralkaliburn.Results:Comparedwiththatofthenormalcontrols,theexpressionoflamininandfibronectinoftheburnedeyeswasdramaticallyhigherat7hours,reachedpeakat14daysanddecreasedtothenormallevelat28daysafteralkaliburn.Conclusions:Intheprocessofwoundhealingafteralkaliburn,theexpressionoflamininandfibronectinincreasesdramatically,whichsuggeststhatlamininandfibronectinmayparticipateintheprocessofcornealwoundhealing.