简介：　　【摘要】 目的 探讨肿瘤患者大量输血后临床检验指标的变化。方法 142例肿瘤患者， 均给予大量输血， 比较输血前后临床检验指标。结果 输血前， 血小板（ PLT）计数为（ 189.22±96.42） ×109/L， 凝血酶原时间（ PT）为（ 15.07±2.67） s， 国际标准化比值（ INR）为（ 1.44±0.46）， 活化部分凝血酶时间（ APTT）为（ 37.61±6.13） s， 纤维蛋白原（ FIB）为（ 2.64±1.13） g/L， 凝血酶时间（ TT）为（ 16.11±2.38） s；输血后， PLT计数为（ 115.01±53.87） ×109/L， PT为（ 16.67±5.21） s， INR为（ 1.26±0.28）， APTT为（ 39.54±7.41） s， FIB为（ 2.21±0.88） g/L， TT为（ 18.33±4.57） s。输血后， 患者 PLT计数、 INR、 FIB均低于输血前， PT、 APTT、 TT均长于输血前， 差异具有统计学意义（ P<0.05）。结论 大量输血对大失血的肿瘤患者是非常重要的治疗手段， 然而临床医生应该高度警惕大量输血以后的各种并发症， 及时对患者的 PLT输血、功能以及凝血功能给予检测， 进而能够有效防治并发症的发生。当大失血的肿瘤患者出血已经停止， 可以考虑限制性输血方式， 进而降低输血不良影响。  　　【关键词】 肿瘤；大量输血；临床检验指标；临床观察  　 [Abstract] Objective To explore the changes of clinical test indexes of tumor patients after massive blood transfusion. Methods 142 tumor patients were given a lot of blood transfusion, and the clinical test indexes before and after blood transfusion were compared. Results before transfusion, PLT was (189.22 ± 96.42) × 109 / L, Pt was (15.07 ± 2.67) s, INR was (1.44 ± 0.46), APTT was (37.61 ± 6.13) s, FIB was (2.64 ± 1.13) g / L, TT was (16.11 ± 2.38) s, and after transfusion PLT was (115.01 ± 53.87) × 109 / L, Pt was (16.67 ± 5.21) s, INR was (1.26 ± 0.28), APTT was (39.54 ± 7.41) s, FIB was (2.21 ± 0.88) g / L, TT was (18.33 ± 4.57) s. After transfusion, PLT count, INR, FIB were lower than before transfusion, Pt, APTT, TT were longer than before transfusion, the difference was statistically significant (P < 0.05). Conclusion massive blood transfusion is a very important treatment for tumor patients with massive blood loss. However, clinicians should be highly alert to the complications after massive blood transfusion, and timely detect PLT transfusion, function and coagulation function of patients, so as to effectively prevent and treat complications. When the bleeding of tumor patients with massive blood loss has stopped, we can consider the way of limited blood transfusion to reduce the adverse effects of blood transfusion.