简介：摘要目的研究分析慢性阻塞性肺疾病急性加重期(AECOPD)与非小细胞肺癌患者血清HMGB１表达的临床意义.方法选取２０１１年５月１５日－２０１４年５月３０日经我院诊断并治疗的AECOPD患者、非小细胞肺癌患者及同时间体检健康人群作为研究对象,其中AECOPD患者３７例,作为肺病加重组;非小细胞肺癌患者２９例,作为肺癌实验组;健康人群４４例,作为正常对照组.分别检测三组人群的HMGB１、外周血白细胞计数、C－反应蛋白水平及肺癌标志物－癌胚抗原,并比较.结果肺病加重组患者的HMGB１、外周血白细胞计数(WBC)及C－反应蛋白(CRP)水平均明显高于正常对照组;肺癌实验组患者的HMGB１、癌胚抗原(CEA)水平均明显高于正常对照组,P均＜０．０５,均具有统计学意义.结论AECOPD与非小细胞肺癌患者的血清HMGB１水平均有明显升高,提示血清HMGB１与其发病有重要关系.关键字AECOPD;非小细胞肺癌;血清HMGB１;临床意义ResearchthesignificanceofserumHMGB１expressioninAECOPDandnon－smallcelllungcancerAbstractObjectiveToresearchandanalyzethesignificanceofserumHMGB１expressioninAECOPDandnon－smallcelllungcancer．MethodSelectedAECOPDandnon－smallcelllungcancerpatientswhoacceptedtreatmentinourhospitalfrom１５,May２０１１to３０,May２０１４asresearchobject,including３７patientsasseriouslungdiseasegroup,and３２non－smallcelllungcancerpatientsaslungcancergroup;４４healthpeopleascontrolgroup．Detectedandcomparedthreegroups’HMGB１,peripheralbloodwhitecellamount,C－reactionproteinlevelandlungcancerlandmark－CEA．ResultHMGB１,peripheralbloodwhitecellamount(WBC),C－reactionproteinlevel(CRP)andlungcancerlandmark－CEAofseriouslungdiseasegroupwerehigherthanthoseofcontrolgroup;HMGB１,peripheralbloodwhitecellamount(WBC),C－reactionproteinlevel(CRP)andlungcancerlandmark－CEAoflungcancergroupwerehigherthanthoseofcontrolgroup,allP＜０．０５,withstatisticalsignificance．ConclusionTheincreaseofserumKHeyMwGorBd１expressionofAECOPDandnon－smallcelllungcancerpatientssuggestthatserumHMGB１hasrelationshipwithpatients’morbidity．AECOPD;non－smalllungcancer;SerumHMGB１;Clinicalsignificance中图分类号R７３４．２文献标识码B文章编号１００８－６３１５(２０１５)１２－０２５７－０１