不同他汀类药物治疗早发冠心病急性心肌梗死患者近期临床效果

　　【摘要】 目的 评价不同他汀类药物治疗早发冠心病急性心肌梗死的近期临床疗效。方法 100例早发冠心病急性心肌梗死患者， 根据治疗药物不同分为观察组与对照组， 各 50例。两组均采用常规治疗， 此外对照组给予瑞舒伐他汀治疗， 观察组给予阿托伐他汀治疗。治疗前及治疗结束后即对两组甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、总胆固醇水平进行检测比较， 并观察不良反应发生情况。结果 治疗前， 两组甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和总胆固醇水平比较差异无统计学意义（ P>0.05） ;治疗后， 观察组的甘油三酯水平（ 1.65±1.32） mmol/L、低密度脂蛋白胆固醇水平（ 3.70±0.68） mmol/L、高密度脂蛋白胆固醇水平（ 1.87±1.15） mmol/L、总胆固醇水平（ 5.61±0.99） mmol/L均优于对照组的（ 2.43±1.86）、（ 4.11±0.70）、（ 1.46±0.73）、（ 6.32±1.94） mmol/L， 差异均具有统计学意义（ P<0.05）。观察组不良反应发生率 8.00%显著低于对照组的 28.00%， 差异具有统计学意义（ P<0.05）。结论 相较瑞舒伐他汀， 阿托伐他汀对早发冠心病急性心肌梗死患者的治疗更为优异。  　　【关键词】 他汀类药物 ;早发冠心病 ;急性心肌梗死 ;临床疗效  　　 [Abstract] Objective To evaluate the short-term clinical efficacy of different statins in the treatment of acute myocardial infarction of early coronary heart disease. Methods 100 patients with acute myocardial infarction of early coronary heart disease were divided into observation group and control group according to different drugs, 50 cases in each group. In addition, the control group was treated with rosuvastatin, and the observation group was treated with atorvastatin. Before and after treatment, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and total cholesterol were detected and compared between the two groups, and adverse reactions were observed. Results before the treatment, there was no significant difference in the levels of TG, LDL-C, HDL-C and TC between the two groups (P > 0.05); after the treatment, the levels of TG (1.65 ± 1.32) mmol / L, LDL-C (3.70 ± 0.68) mmol / L, HDL-C (1.87 ± 1.15) mmol / L and TC in the observation group The level of cholesterol (5.61 ± 0.99) mmol / l was significantly higher than that of the control group (2.43 ± 1.86), (4.11 ± 0.70), (1.46 ± 0.73), (6.32 ± 1.94) mmol / L (P < 0.05). The incidence of adverse reactions in the observation group was 8.00%, which was significantly lower than that in the control group (28.00%) (P < 0.05). Conclusion compared with rosuvastatin, atorvastatin is superior in the treatment of early-onset acute myocardial infarction.

• 作者: 靳洪文
• 出处: 《世界复合医学》 2019年9期
• 分类: [医药卫生][临床医学]