摘要
Objective:Toobservetheeffectofacupunctureonhyperleptinaemiaandhyperinsulinemiaforstudyingitsunderlyingmechanismaboutanti-obesityandreducingbloodlipidinobesityrats.Methods:Atotalof80SDratswererandomizedintonormalcontrol,model,acupunctureandmedicationgroups,with20casesineachgroup.Hypothalamicobesitymodelwasestablishedbysubcutaneousinjectionof15%sodiumglutamate(0.2mL/10gbodyweight),oncedailyandcontinuouslyfor5days.'Zusanli'(足三里ST36),'Sanyinjiao'(三阴交SP6),'Guanyuan'(关元CV4)and'Zhongwan'(中脘CV12)werepuncturedandstimulatedelectrically(100Hz,dense-sparsewaves,andasuitablestrengthinducinglocalmusculartremor)for15min,oncedaily.Inmedicationgroup,ratswerefedwithSibutramine4mg/kg,oncedaily.After4weeks'treatment,Lee'sindexwasdetected,andserumleptinandinsulincontentsweredeterminedbyradioimmunoassay(RIA).Results:Comparedwithnormalcontrolgroup,Lee'sindex,serumleptinandinsulincontentsofmodelgroupincreasedsignificantly(P<0.01).Comparisonbetweenacupunctureandmodelgroups,Lee'sindexandserumleptinofacupuncturegroupdecreasedsignificantly(P<0.01),andseruminsulinlevelalsolowered.Incomparisonwithmodelgroup,Lee'sindex,serumleptinandinsulinlevelsofmedicationgroupalsolowered.ComparisonbetweenacupunctureandmedicationgroupsshowedthatLee'sindexandserumleptinlevelofacupuncturegroupweresignificantlylowerthanthoseofthelatergroup(P<0.01),displayingthatthetherapeuticeffectofacupunctureisbetterthanthatofSibutramineinloweringLee'sindexandserumleptin.Nosignificantdifferenceswerefoundbetweenacupunctureandmedicationgroupsinbodyweightandlengthandseruminsulin(P>0.05).Conclusion:AcupuncturecaneffectivelyreduceLee'sindex,serumleptinandinsulincontentsinfastingobeserats,whichmaycontributetoitseffectinanti-obesity.
出版日期
2005年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
