摘要
EversinceHelicobacterpylori（H.pylori）wasrecognizedasaninfectiouscauseofgastriccancer,therehasbeenincreasinginterestinexaminingitspotentialroleincolorectalcarcinogenesis.Datafromcasecontrolandcross-sectionalstudies,mostlyrelyingonhospital-basedsamples,andseveralmeta-analyseshaveshownapositivestatisticalrelationshipbetweenH.pyloriinfectionandcolorectalneoplasia.However,thepossibilityexiststhattheresultshavebeeninfluencedbybias,includingtheimproperselectionofpatientsanddisparitieswithrespecttopotentialconfounders.Whiletheevidencefallsshortofadefinitivecausallink,itappearsthatinfectionwithH.pylori/H.pylori-relatedgastritisisassociatedwithanincreased,althoughmodest,riskofcolorectaladenomaandcancer.Thepathogenicmechanismsresponsibleforthisassociationremainuncertain.H.pylorihasbeendetectedincolorectalmalignanttissues;however,thepossibilitythatH.pyloriisadirectactivatorofcoloniccarcinogenesisremainspurelyhypothetical.Ontheotherhand,experimentaldatahaveindicatedaseriesofpotentialoncogenicinteractionsbetweenthesebacteriaandcolorectalmucosa,includinginductionandperpetuationofinflammatoryresponses,alterationofgutmicrofloraandreleaseoftoxinsand/orhormonalmediators,suchasgastrin,whichmaycontributetotumorformation.
出版日期
2016年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
