摘要
Thereisaneedtostandardizemethodsassociatedwiththedispersionofnanomaterialsinnano（eco）toxicologicalinvestigations.Thefirststeptowardthisgoalistounderstandthedegreeofvariabilitythatexistsinnanomaterialdispersionspreparedbyusingdifferentprotocols.Usingtwocasestudies,thedegreeofvariabilityinTiO2nanomaterialdispersionswasassessedbydifferentialcentrifugalsedimentation（DCS）methods.Casestudy1addressesthevariabilitythatarisesfromvariationswithinoneprotocol,investigatingtheeffectsofdispersionaging,sonicationexposuretime,sonicationinthepresence/absenceofanicebath,materialsubsampling,particleconcentrationandhavingapre-wettingstep.Casestudy2addressesthevariabilitybetweenfourdifferentprotocolsdevelopedthroughpastresearchactivitiesandprojects.Theresultsindicatethatthereisalargedegreeofvariability（relativestandarddeviation（RSD）ofmeanparticlediameter=26%）inthedispersionofTiO2nanomaterialsbetweenthefourdifferentprotocolsstudiedandthatseveralstepsinadispersionprotocolarepotentialsourcesofvariation,withfinalparticleconcentrationbeingthemostsignificant.Theimplicationofthisstudyisclear:forthepurposeofdatacomparability,thereisaneedtoprovidetheexactdetailsofallstepsinvolvedinadispersionprotocol.
出版日期
2015年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
