Restricting carbohydrates to fight head and neck cancer——is this realistic？-中国期刊网

摘要 Headandneckcancers(HNCs)areaggressivetumorsthattypicallydemonstrateahighglycolyticrate,whichresultsinresistancetocytotoxictherapyandpoorprognosis.Duetotheirlocationthesetumorsspecificallyimpairfoodintakeandqualityoflife,sothatpreventionofweightlossthroughnutritionsupportbecomesanimportanttreatmentgoal.Dietaryrestrictionofcarbohydrates(CHOs)andtheirreplacementwithfat,mostlyinformofaketogenicdiet(KD),havebeensuggestedtoaccommodateforboththealteredtumorcellmetabolismandcancer-associatedweightloss.Inthisreview,IpresentthreespecificrationalesforCHOrestrictionandnutritionalketosisassupportivetreatmentoptionsfortheHNCpatient.Theseare(1)targetingtheoriginandspecificaspectsoftumorglycolysis;(2)protectingnormaltissuefrombutsensitizingtumortissuetoradiation-andchemotherapyinducedcellkill;(3)supportingbodyandmusclemassmaintenance.WhilemostofthesebenefitsofCHOrestrictionapplytocanceringeneral,specificaspectsofimplementationarediscussedinrelationtoHNCpatients.WhileCHOrestrictionseemsfeasibleinHNCpatientstheavailableevidenceindicatesthatitsrolemayextendbeyondfightingmalnutritiontofightingHNCitself.

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Restricting carbohydrates to fight head and neck cancer——is this realistic？

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Restricting carbohydrates to fight head and neck cancer——is this realistic？

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