摘要
CytochromeP450(CYP)superfamilyisoneofthemembershiplargestandfunctionmostdiverseproteinsuperfamilyrecogniozedamonglivingbeings.Membersofthissuperfamilywerefurtherassignedtodifferentfamiliesandsubfamiliesbasedontheiraminoacidsimilarities.Accordingtotheirphylogeneticrelationships,theCYPgeneswhichlikelydivergedfromcommonancestorgeneandmaysharecommonfunctionsweregroupedintooneclan.Widelydistributingscallopsareagroupofthemostconspicuousbivalve;howeverthestudiesontheirCYPisacarce.Inthisstudy,wesearchedthegenomeandexpressedsequencetagsofZhikongscallop(Chlamysfarreri)forCYPgenes.Intotal,88non-redundantCYPwereidentified,whichwerehomedin13CYPsgenefamilies.Phylogeneticanalysisdividedthesegenesinto4CYPclans.Asindeuterostomes,Clan2wasthelargest,whichcontained33genesbelongingtoCYP1,CYP2,CYP17andCYP356families.Clan3contgained19genesbelongingtoCYP3,CYP5andCYP30families.Clan4contained23genes,allbelongingtoCYP4family.ThemitochondrialCYPclancontained9genesbelongingtoCYP10andCYP24families.Incomparison,protostomes(C.farreri,D.pluex,D.melanogaster)containedmoreCYPgenesthandeuterostomes(S.purpuratusandvertebrates)inClan2butlessgenesinClan3andClan4.OurfindingswillaidtodecipheringCYPfunctionandevolutioninscallopsandbivalves.
出版日期
2013年01月11日(中国期刊网平台首次上网日期,不代表论文的发表时间)