CTL Response Suppression in Chronic Phase of Infection： A mathematical study-中国期刊网

摘要 Humanimmunodeficiencyvirus(HIV)hashadaninsightfulimpactaboutthestateofhealthinessofhumanimmunesystem.Duetogreatimprovementindrugtherapy,HIVinfectionshavebeenreducedby17%overthepasteightyears.IthasbeenprovedthatmosteffectivetreatmentHAART(HighlyActiveAntiRetroviralTherapy)mainlycontrolsthediseasesprogressionbutitdoesnoteradicatethediseasescompletely.ReverseTranscriptaseInhibitordrugsspeciallyassociatedwithvirusspecificCytotoxicT-Lymphocyte(CTL)thatdeclineswithdiseaseprogression.CTLresponsesagainstAIDSpathogenesiscouldbepotentialinthedynamicsofvirusreplication,recognitionandclearanceofinfectedcells.InthisresearcharticleamathematicalmodelhasbeenproposedonthebasisofCTLresponsesuppressioninthechronicphaseofinfectionduetopresenceofvirus.WealsoconsiderthegrowthoftheviruspopulationfromtheinfectedCD4~+Tcellsbuddingprocessandfromtheotherinfectedcellslikemacrophagesandthymocytes.Ouranalyticalandnumericalstudiesareconsistentwithexistingobservationsfromalliedareas.

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CTL Response Suppression in Chronic Phase of Infection： A mathematical study

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CTL Response Suppression in Chronic Phase of Infection： A mathematical study

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