The role of heredity in pterygium development-中国期刊网

摘要 Severalriskfactors,whichincludeheredity,ultra-violet(UV)lightandchronicinflammation,contributetopterygiumdevelopment.However,thereisnoreportintegratingthesefactorsinthepathogenesisofpterygium.Theaimofthisreviewistodescribetheconnectionbetweenheredity,UV,andinflammationinpterygiumdevelopment.ExistingreportsindicatethatsunlightexposureisthemainfactorinpterygiumoccurrencebyinducinggrowthfactorproductionorchronicinflammationorDNAdamage.Hereditymaybeafactor.Ourstudiesonfactorsinpterygiumoccurrenceandrecurrenceidentifythatheredityiscrucialforpterygiumtodevelop,andthatsunlightisonlyatrigger,andthatchronicinflammationpromotespterygiumenlargement.WeproposethatgeneticfactorsmayinterferewiththecontroloffibrovascularproliferationwhileUVlightor(sunlight)mostlikelyonlytriggerspterygiumdevelopmentbyinducinggrowthfactorswhichpromotevibrantfibrovascularproliferationinpredisposedindividuals.Italsojusttriggersinflammationandcollagenolysis,whichmaybepromotersoftheenlargementofthefibrovascularmass.Pterygiumprobablyoccursinthepresenceofexuberantcollagenproductionandprofuseneovascularisation.

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The role of heredity in pterygium development

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The role of heredity in pterygium development

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